Mitochondrial dysfunction in skeletal muscle pathologies

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Cristian Vilosc, Claudio Cabello-Verrugio*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Several molecular mechanisms are involved in the regulation of skeletal muscle function. Among them, mitochondrial activity can be identified. The mitochondria is an important and essential organelle in the skeletal muscle that is involved in metabolic regulation and ATP production, which are two key elements of muscle contractibility and plasticity. Thus, in this review, we present the critical and recent antecedents regarding the mechanisms through which mitochondrial dysfunction can be involved in the generation and development of skeletal muscle pathologies, its contribution to detrimental functioning in skeletal muscle and its crosstalk with other typical signaling pathways related to muscle diseases. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious impact of mitochondrial dysfunction in skeletal muscle is discussed.

Original languageEnglish
Pages (from-to)536-546
Number of pages11
JournalCurrent Protein and Peptide Science
Volume20
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Bentham Science Publishers.

Keywords

  • ATP production
  • Atrophy
  • Dystrophy
  • Mitochondria
  • ROS
  • Skeletal muscle

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