Microtechnology applied to stem cells research and development

Juan Pablo Acevedo, Ioannis Angelopoulos, Danny Van Noort, Maroun Khoury

Research output: Contribution to journalScientific reviewpeer-review

1 Scopus citations

Abstract

Microfabrication and microfluidics contribute to the research of cellular functions of cells and their interaction with their environment. Previously, it has been shown that microfluidics can contribute to the isolation, selection, characterization and migration of cells. This review aims to provide stem cell researchers with a toolkit of microtechnology (mT) instruments for elucidating complex stem cells functions which are challenging to decipher with traditional assays and animal models. These microdevices are able to investigate about the differentiation and niche interaction, stem cells transcriptomics, therapeutic functions and the capture of their secreted microvesicles. In conclusion, microtechnology will allow a more realistic assessment of stem cells properties, driving and accelerating the translation of regenerative medicine approaches to the clinic.
Original languageAmerican English
Pages (from-to)233-248
Number of pages16
JournalRegenerative Medicine
Volume13
Issue number2
DOIs
StatePublished - 1 Mar 2018

Keywords

  • cancer
  • differentiation
  • microfabrication
  • microfluidics
  • microtechnology
  • regenerative medicine
  • stem cells
  • translational medicine

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