TY - JOUR
T1 - Micrornas and their role in the malignant transformation of oral leukoplakia
T2 - A scoping review
AU - Niklander, Sven
AU - Guerra, Daniela
AU - Contreras, Felipe
AU - González-Arriagada, Wilfredo
AU - Marín, Constanza
N1 - Funding Information:
This research received financial support from Andres Bello University grant UNAB-DI-02-19/CB.
Publisher Copyright:
© Medicina Oral S. L. C.I.F.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Background: MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods: We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results: Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial–mesenchymal transition, invasion and migration. Conclusions: Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers.
AB - Background: MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods: We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results: Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial–mesenchymal transition, invasion and migration. Conclusions: Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers.
KW - Biomarkers
KW - Malignant transformation
KW - MiRNAs
KW - Oral leukoplakia
KW - Oral squamous cell carcinoma
KW - Biomarkers
KW - Malignant transformation
KW - MiRNAs
KW - Oral leukoplakia
KW - Oral squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85122043284&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b0f6df76-a6ef-3fed-8bb2-5499270a0325/
U2 - 10.4317/medoral.24975
DO - 10.4317/medoral.24975
M3 - Article
C2 - 34564679
AN - SCOPUS:85122043284
SN - 1698-4447
VL - 27
SP - e77-e84
JO - Medicina Oral Patologia Oral y Cirugia Bucal
JF - Medicina Oral Patologia Oral y Cirugia Bucal
IS - 1
M1 - 24975
ER -