Mesenchymal stem cells in osteoarticular pediatric diseases: an update.

German A. Norambuena, Maroun Khoury, Christian Jorgensen

Research output: Contribution to journalScientific reviewpeer-review

30 Scopus citations

Abstract

Cellular therapy has gained an increasing popularity in recent years. Mesenchymal stem cells (MSCs) have the potential to differentiate into bone, cartilage, or fat tissue. In recent studies, these cells have also shown healing capability by improving angiogenesis and preventing fibrosis, which could have a role in tissue repair and tissue regeneration. Preclinical and clinical orthopedic studies conducted in the adult population support the use of MSCs for bone-healing problems, early stages of osteonecrosis, and local bone defects. Only a few published studies support the use of MSCs in pediatric osteoarticular disorders, probably due to the unknown long-term results of cellular therapy. The purpose of this review is to explain the mechanism by which MSCs could exhibit a therapeutic role in pediatric osteoarticular disorders.
Original languageAmerican English
Pages (from-to)452-458
Number of pages7
JournalPediatric Research
Volume71
Issue number4 Pt 2
DOIs
StatePublished - 1 Jan 2012

Fingerprint Dive into the research topics of 'Mesenchymal stem cells in osteoarticular pediatric diseases: an update.'. Together they form a unique fingerprint.

Cite this