Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response

Noymar Luque-Campos, Rafael A. Contreras-López, María Jose Paredes-Martínez, Maria Jose Torres, Sarah Bahraoui, Mingxing Wei, Francisco Espinoza, Farida Djouad, Roberto Javier Elizondo-Vega, Patricia Alejandra Luz Crawford

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

In the last years, mesenchymal stem cell (MSC)-based therapies have become an interesting therapeutic opportunity for the treatment of rheumatoid arthritis (RA) due to their capacity to potently modulate the immune response. RA is a chronic autoimmune inflammatory disorder with an incompletely understood etiology. However, it has been well described that peripheral tolerance defects and the subsequent abnormal infiltration and activation of diverse immune cells into the synovial membrane, are critical for RA development and progression. Moreover, the imbalance between the immune response of pro-inflammatory and anti-inflammatory cells, in particular between memory Th17 and memory regulatory T cells (Treg), respectively, is well admitted to be associated to RA immunopathogenesis. In this context, MSCs, which are able to alter the frequency and function of memory lymphocytes including Th17, follicular helper T (Tfh) cells and gamma delta (γδ) T cells while promoting Treg cell generation, have been proposed as a candidate of choice for RA cell therapy. Indeed, given the plasticity of memory CD4+ T cells, it is reasonable to think that MSCs will restore the balance between pro-inflammatory and anti-inflammatory memory T cells populations deregulated in RA leading to prompt their therapeutic function. In the present review, we will discuss the role of memory T cells implicated in RA pathogenesis and the beneficial effects exerted by MSCs on the phenotype and functions of these immune cells abnormally regulated in RA and how this regulation could impact RA progression.

Original languageEnglish
Article number798
JournalFrontiers in Immunology
Volume10
Issue numberMAR
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This work was supported by Fondo Nacional de Desarrollo Científico y Tecnológico 408 (FONDECYT) Iniciación 11160929, Inserm, the University of Montpellier and the Société Française de Rhumatologie (SFR).

Publisher Copyright:
© 2019 Luque-Campos, Contreras-López, Jose Paredes-Martínez, Torres, Bahraoui, Wei, Espinoza, Djouad, Elizondo-Vega and Luz-Crawford. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

  • Immunomodulatory
  • Mesenchymal stem cells
  • Plasticity
  • Rheumatoid arthritis
  • T cell

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