Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Pamina Contreras-Kallens; Claudia Terraza; Karina Oyarce; Tania Gajardo; Mauricio Campos-Mora; María Teresa Barroilhet; Carla Álvarez; Ricardo Fuentes; Fernando Figueroa; Maroun Khoury; Karina Pino-Lagos

doi:10.1111/nyas.13364

Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Pamina Contreras-Kallens, Claudia Terraza, Karina Oyarce, Tania Gajardo, Mauricio Campos-Mora, María Teresa Barroilhet, Carla Álvarez, Ricardo Fuentes, Fernando Figueroa, Maroun Khoury, Karina Pino-Lagos^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.

Original language	English
Pages (from-to)	35-56
Number of pages	22
Journal	Annals of the New York Academy of Sciences
Volume	1417
Issue number	1
DOIs	https://doi.org/10.1111/nyas.13364
State	Published - 2016

Bibliographical note

Funding Information:
This work was supported by FONDECYT 11121309 and 1160347 and PMI UAN1301 Grants.

Publisher Copyright:
© 2017 New York Academy of Sciences.

Keywords

Immunosuppression
MSC
T cells
Therapy
Tolerance
Transplantation

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title = "Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance",

abstract = "Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.",

keywords = "Immunosuppression, MSC, T cells, Therapy, Tolerance, Transplantation",

author = "Pamina Contreras-Kallens and Claudia Terraza and Karina Oyarce and Tania Gajardo and Mauricio Campos-Mora and Barroilhet, {Mar{\'i}a Teresa} and Carla {\'A}lvarez and Ricardo Fuentes and Fernando Figueroa and Maroun Khoury and Karina Pino-Lagos",

note = "Funding Information: This work was supported by FONDECYT 11121309 and 1160347 and PMI UAN1301 Grants. Publisher Copyright: {\textcopyright} 2017 New York Academy of Sciences.",

year = "2016",

doi = "10.1111/nyas.13364",

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AU - Contreras-Kallens, Pamina

AU - Terraza, Claudia

AU - Oyarce, Karina

AU - Gajardo, Tania

AU - Campos-Mora, Mauricio

AU - Barroilhet, María Teresa

AU - Álvarez, Carla

AU - Fuentes, Ricardo

AU - Figueroa, Fernando

AU - Khoury, Maroun

AU - Pino-Lagos, Karina

PY - 2016

Y1 - 2016

N2 - Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.

AB - Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.

KW - Immunosuppression

KW - MSC

KW - T cells

KW - Therapy

KW - Tolerance

KW - Transplantation

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DO - 10.1111/nyas.13364

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JO - Annals of the New York Academy of Sciences

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Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Abstract

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Keywords

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