Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Pamina Contreras-Kallens, Claudia Terraza, Karina Oyarce, Tania Gajardo, Mauricio Campos-Mora, María Teresa Barroilhet, Carla Álvarez, Ricardo Fuentes, Fernando Figueroa, Maroun Khoury, Karina Pino-Lagos

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.

Original languageEnglish
Pages (from-to)35-56
Number of pages22
JournalAnnals of the New York Academy of Sciences
Volume1417
Issue number1
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
This work was supported by FONDECYT 11121309 and 1160347 and PMI UAN1301 Grants.

Publisher Copyright:
© 2017 New York Academy of Sciences.

Keywords

  • Immunosuppression
  • MSC
  • T cells
  • Therapy
  • Tolerance
  • Transplantation

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