Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review

Fernando E. Figueroa, Flavio Carrión, Sandra Villanueva, Maroun Khoury

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohńs disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future advances from stem cell science can be expected to pinpoint significant MSC subpopulations and/or stem cell markers for improved regenerative or immunoregulatory properties.
Original languageAmerican English
Pages (from-to)269-277
Number of pages9
JournalBiological Research
Volume45
Issue number3
DOIs
StatePublished - 31 Dec 2012

Keywords

  • Autoimmune diseases
  • Cellular therapy
  • Mesenchymal stem cells

Fingerprint Dive into the research topics of 'Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review'. Together they form a unique fingerprint.

Cite this