Mental disorders & self-injurious thoughts and behaviors predict high risk of role impairment among university students - results from the world mental health international college student initiative

  • Jordi Alonso*
  • , Maria V. Petukhova
  • , Sue Lee
  • , Nancy A. Sampson
  • , Yasmin A. Altwaijri
  • , Ahmad N. AlHadi
  • , Nouf K. Al-Saud
  • , Claes Andersson
  • , Randy P. Auerbach
  • , Laura Ballester
  • , Jason Bantjes
  • , Marcus Bendtsen
  • , Corina Benjet
  • , Anne H. Berman
  • , Paula Carrasco
  • , Silver C.N. Chan
  • , Irina Cohut
  • , Marcelo A. Crockett
  • , Pim Cuijpers
  • , Oana A. David
  • Dong Dong, Jorge Gaete, Mireia Felez-Nobrega, Carlos García Forero, Margalida Gili, Raúl A. Gutiérrez-García, Josep Maria Haro, Xanthe Hunt, Álvaro I. Langer, Irene Léniz, Yan Liu, Scarlett Mac-Ginty, Vania Martínez, Andre Mason, Andrea Miranda-Mendizabal, Daniel Núñez, Claudiu C. Papasteri, José A. Piqueras, Codruta A. Popescu, Charlene Rapsey, Tiscar Rodriguez-Jimenez, Wylene Saal, Oi ling Siu, Dan J. Stein, Sascha Y. Struijs, Cristina T.Tomoiaga, Samuel Y.S. Wong, Gemma Vilagut, Ronald C. Kessler
*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective We examined psychopathological conditions accounting for the highest risk of role impairment among university students. Method Cross-sectional online survey of first-year students (60 universities, 10 countries) assessing role impairment due to emotional problems in previous 30 days with the 3-item emotional subscale of the VR-36. Cross-tabulations and Poisson regression examined associations between 12 psychopathological conditions (8 probable mental disorders and 4 SITB) and socio-demographics with “significant role impairment” (“most”/”all of the time” in 2+ VR-36 items). We used machine learning methods to predict probabilities (risk) of significant role impairment based on the 12 psychopathological conditions. Observed prevalence of significant role impairment was examined within and across the 20 population ventiles to assess risk concentration using sensitivity (SN) and positive predictive value (PPV). Results 43,990 students responded to the survey (median age = 19, IQR = 18–23). 27.1 % had significant role impairment due to emotional problems and 65.8 % had at least one psychopathological condition. Students with one or more of these conditions were more likely to have significant impairment than those without (RR = 3.9; 95 %CI: 3.6–4.2). In multivariable analyses, probable Depression and Bipolar disorders were the strongest correlates of significant impairment. Most (69.6 %) of the observed significant role impairment occurred among the roughly 35 % of respondents with highest predicted risk (PPV = 53.2 %). Conclusion Significant role impairment due to emotional problems is highly prevalent among university students. High risk of significant role impairment concentrates in one third of the students, those with several psychopathological conditions. Assessing these conditions should help identifying highest role impairment risk university students.

Original languageEnglish
Article number120847
JournalJournal of Affective Disorders
Volume397
DOIs
StatePublished - 15 Mar 2026

Bibliographical note

Publisher Copyright:
Copyright © 2025. Published by Elsevier B.V.

Keywords

  • mental disorders
  • risk concentration
  • risk prediction
  • role impairment
  • self-injurious thoughts and behaviors
  • targeted interventions
  • university students

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