Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro

Francisca Alcayaga-Miranda; Maroun Khoury

Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro

Francisca Alcayaga-Miranda (Inventor), Maroun Khoury (Inventor)

Research output: Patent

Abstract

The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stem cells (MenSCs) may be cultured in vitro and exhibit mesenchymal stem cell (MSC)-like properties and some culture and expansion advantages. This population of Men SCs, compared to the broadly studied bone marrow derived stem cells (BM-MSCs) out- performs bone marrow derived mesenchymal stem cells in proliferation rate and support of hematopoietic stem cell (HSC) expansion in vitro. MenSCs demonstrate to maintain their stem cell properties over 2 years, being genetically stable, without expressing surface differentiation markers, and they also show the ability to differentiate into adipocytes, chondrocytes and osteoblast cells. MenSCs can be easily and periodically obtained, isolated and cultured.

Original language	English
Patent number	WO/2014/135924
State	Accepted/In press - 2014

Cite this

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title = "Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro",

abstract = "The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stem cells (MenSCs) may be cultured in vitro and exhibit mesenchymal stem cell (MSC)-like properties and some culture and expansion advantages. This population of Men SCs, compared to the broadly studied bone marrow derived stem cells (BM-MSCs) out- performs bone marrow derived mesenchymal stem cells in proliferation rate and support of hematopoietic stem cell (HSC) expansion in vitro. MenSCs demonstrate to maintain their stem cell properties over 2 years, being genetically stable, without expressing surface differentiation markers, and they also show the ability to differentiate into adipocytes, chondrocytes and osteoblast cells. MenSCs can be easily and periodically obtained, isolated and cultured.",

author = "Francisca Alcayaga-Miranda and Maroun Khoury",

year = "2014",

language = "English",

type = "Patent",

note = "WO/2014/135924",

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TY - PAT

T1 - Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro

AU - Alcayaga-Miranda, Francisca

AU - Khoury, Maroun

PY - 2014

Y1 - 2014

N2 - The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stem cells (MenSCs) may be cultured in vitro and exhibit mesenchymal stem cell (MSC)-like properties and some culture and expansion advantages. This population of Men SCs, compared to the broadly studied bone marrow derived stem cells (BM-MSCs) out- performs bone marrow derived mesenchymal stem cells in proliferation rate and support of hematopoietic stem cell (HSC) expansion in vitro. MenSCs demonstrate to maintain their stem cell properties over 2 years, being genetically stable, without expressing surface differentiation markers, and they also show the ability to differentiate into adipocytes, chondrocytes and osteoblast cells. MenSCs can be easily and periodically obtained, isolated and cultured.

AB - The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stem cells (MenSCs) may be cultured in vitro and exhibit mesenchymal stem cell (MSC)-like properties and some culture and expansion advantages. This population of Men SCs, compared to the broadly studied bone marrow derived stem cells (BM-MSCs) out- performs bone marrow derived mesenchymal stem cells in proliferation rate and support of hematopoietic stem cell (HSC) expansion in vitro. MenSCs demonstrate to maintain their stem cell properties over 2 years, being genetically stable, without expressing surface differentiation markers, and they also show the ability to differentiate into adipocytes, chondrocytes and osteoblast cells. MenSCs can be easily and periodically obtained, isolated and cultured.

M3 - Patent

M1 - WO/2014/135924

ER -