In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the ÷2 minimization method, is employedconcluding that the Korsmeyer-Peppas modelprovides the best-ûtin all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.
|Number of pages||6|
|Journal||Biomedical and Pharmacology Journal|
|State||Published - 28 Dec 2018|
Bibliographical notePublisher Copyright:
© 2018 Oriental Scientific Publishing Company.
- Drug dissolution
- Least squares method
- Mathematical modelling
- Model comparison
- Release kinetics
- Statistical analysis