Mathematical modeling for pharmacokinetic predictions from controlled drug release nano systems: A comparative parametric study

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Abstract

In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the ÷2 minimization method, is employedconcluding that the Korsmeyer-Peppas modelprovides the best-ûtin all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.
Original languageAmerican English
Pages (from-to)1801-1806
Number of pages6
JournalBiomedical and Pharmacology Journal
Volume11
Issue number4
DOIs
StatePublished - 1 Dec 2018

Keywords

  • Drug dissolution
  • Least squares method
  • Mathematical modelling
  • Model comparison
  • Release kinetics
  • Statistical analysis

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