Maternal serum transformed α-fetoprotein levels in women with intrauterine growth retardation

Jose L. Bartha, Sebastian Illanes, Fernando González-Bugatto, Sherif A. Abdel-Fattah, Gerald J. Mizejewski, Peter W. Soothill

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective: To evaluate maternal serum transformed α-fetoprotein (t-AFP) levels in women with intrauterine growth retardation (IUGR). Methods: 60 pregnant women in two groups were studied: 30 with IUGR and 30 healthy pregnant women as a control group. t-AFP concentrations were determined by ELISA assay. Results: Maternal serum t-AFP levels were higher in women with IUGR than in the control group: 15.39 (10.81-24.01) ng/ml vs. 8.66 (6.22-13.45) ng/ml (p = 0.003). t-AFP levels were even higher in those with fetal hemodynamic redistribution 21.08 (16.02-40.85) ng/ml than in those without 12.15 (10.48-17.45) ng/ml (p = 0.03). Conclusions: Maternal serum t-AFP is increased in women with IUGR and this elevation is marked in those with fetal hemodynamic redistribution. Copyright
Original languageAmerican English
Pages (from-to)294-298
Number of pages5
JournalFetal Diagnosis and Therapy
Volume22
Issue number4
DOIs
StatePublished - 1 Jun 2007
Externally publishedYes

Keywords

  • α-Fetoprotein
  • Growth retardation
  • Pregnancy complications

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