Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos; Attilio Rigotti; Dolores Busso; Loni Berkowitz; José L. Santos; Gisella R. Borzone; José A. Poblete; Claudio Vera; Cristián Belmar; Denisse Goldenberg; Bárbara Samith; Ana M. Acosta; Manuel Escalona; Ian Niklitschek; Jorge R. Mandiola; Nicolás Mertens

doi:10.1002/oby.20816

Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos^*
, Attilio Rigotti
, Dolores Busso
, Loni Berkowitz
, José L. Santos
, Gisella R. Borzone
, José A. Poblete
, Claudio Vera
, Cristián Belmar
, Denisse Goldenberg
, Bárbara Samith
, Ana M. Acosta
, Manuel Escalona
, Ian Niklitschek
, Jorge R. Mandiola
, Nicolás Mertens

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (R_SPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (R_SPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

Original language	English
Pages (from-to)	2156-2163
Number of pages	8
Journal	Obesity
Volume	22
Issue number	10
DOIs	https://doi.org/10.1002/oby.20816
State	Published - 1 Oct 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 The Obesity Society. 2014.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/oby.20816

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Olmos, P. R., Rigotti, A., Busso, D., Berkowitz, L., Santos, J. L., Borzone, G. R., Poblete, J. A., Vera, C., Belmar, C., Goldenberg, D., Samith, B., Acosta, A. M., Escalona, M., Niklitschek, I., Mandiola, J. R., & Mertens, N. (2014). Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes. Obesity, 22(10), 2156-2163. https://doi.org/10.1002/oby.20816

@article{6a2bcbe22b0645fb93ee249e801e3105,

title = "Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes",

abstract = "Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (\%) = 10.1\%, 19.0\% and 30.4\% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (\%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.",

keywords = "Adult, Body Weight, Diabetes, Gestational, Female, Fetal Macrosomia, Gestational Age, Humans, Hypertriglyceridemia, Infant, Newborn, Obesity, Pregnancy, Pregnancy Complications, Prospective Studies",

author = "Olmos, \{Pablo R.\} and Attilio Rigotti and Dolores Busso and Loni Berkowitz and Santos, \{Jos{\'e} L.\} and Borzone, \{Gisella R.\} and Poblete, \{Jos{\'e} A.\} and Claudio Vera and Cristi{\'a}n Belmar and Denisse Goldenberg and B{\'a}rbara Samith and Acosta, \{Ana M.\} and Manuel Escalona and Ian Niklitschek and Mandiola, \{Jorge R.\} and Nicol{\'a}s Mertens",

note = "Publisher Copyright: {\textcopyright} 2014 The Obesity Society. 2014.",

year = "2014",

month = oct,

day = "1",

doi = "10.1002/oby.20816",

language = "English",

volume = "22",

pages = "2156--2163",

journal = "Obesity",

issn = "1930-7381",

publisher = "John Wiley and Sons Inc.",

number = "10",

}

Olmos, PR, Rigotti, A, Busso, D, Berkowitz, L, Santos, JL, Borzone, GR, Poblete, JA, Vera, C, Belmar, C, Goldenberg, D, Samith, B, Acosta, AM, Escalona, M, Niklitschek, I, Mandiola, JR & Mertens, N 2014, 'Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes', Obesity, vol. 22, no. 10, pp. 2156-2163. https://doi.org/10.1002/oby.20816

TY - JOUR

T1 - Maternal hypertriglyceridemia

T2 - A link between maternal overweight-obesity and macrosomia in gestational diabetes

AU - Olmos, Pablo R.

AU - Rigotti, Attilio

AU - Busso, Dolores

AU - Berkowitz, Loni

AU - Santos, José L.

AU - Borzone, Gisella R.

AU - Poblete, José A.

AU - Vera, Claudio

AU - Belmar, Cristián

AU - Goldenberg, Denisse

AU - Samith, Bárbara

AU - Acosta, Ana M.

AU - Escalona, Manuel

AU - Niklitschek, Ian

AU - Mandiola, Jorge R.

AU - Mertens, Nicolás

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

AB - Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

KW - Adult

KW - Body Weight

KW - Diabetes

KW - Gestational

KW - Female

KW - Fetal Macrosomia

KW - Gestational Age

KW - Humans

KW - Hypertriglyceridemia

KW - Infant

KW - Newborn

KW - Obesity

KW - Pregnancy

KW - Pregnancy Complications

KW - Prospective Studies

UR - https://www.scopus.com/pages/publications/84907662729

U2 - 10.1002/oby.20816

DO - 10.1002/oby.20816

M3 - Article

C2 - 24957884

AN - SCOPUS:84907662729

SN - 1930-7381

VL - 22

SP - 2156

EP - 2163

JO - Obesity

JF - Obesity

IS - 10

ER -

Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Abstract

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