Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos; Attilio Rigotti; Dolores Busso; Loni Berkowitz; José L. Santos; Gisella R. Borzone; José A. Poblete; Claudio Vera; Cristián Belmar; Denisse Goldenberg; Bárbara Samith; Ana M. Acosta; Manuel Escalona; Ian Niklitschek; Jorge R. Mandiola; Nicolás Mertens

doi:10.1002/oby.20816

Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos^*, Attilio Rigotti, Dolores Busso, Loni Berkowitz, José L. Santos, Gisella R. Borzone, José A. Poblete, Claudio Vera, Cristián Belmar, Denisse Goldenberg, Bárbara Samith, Ana M. Acosta, Manuel Escalona, Ian Niklitschek, Jorge R. Mandiola, Nicolás Mertens

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (R_SPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (R_SPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

Original language	English
Pages (from-to)	2156-2163
Number of pages	8
Journal	Obesity
Volume	22
Issue number	10
DOIs	https://doi.org/10.1002/oby.20816
State	Published - 1 Oct 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 The Obesity Society. 2014.

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10.1002/oby.20816

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Olmos, P. R., Rigotti, A., Busso, D., Berkowitz, L., Santos, J. L., Borzone, G. R., Poblete, J. A., Vera, C., Belmar, C., Goldenberg, D., Samith, B., Acosta, A. M., Escalona, M., Niklitschek, I., Mandiola, J. R., & Mertens, N. (2014). Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes. Obesity, 22(10), 2156-2163. https://doi.org/10.1002/oby.20816

@article{6a2bcbe22b0645fb93ee249e801e3105,

title = "Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes",

abstract = "Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.",

keywords = "Adult, Body Weight, Diabetes, Gestational, Female, Fetal Macrosomia, Gestational Age, Humans, Hypertriglyceridemia, Infant, Newborn, Obesity, Pregnancy, Pregnancy Complications, Prospective Studies",

author = "Olmos, {Pablo R.} and Attilio Rigotti and Dolores Busso and Loni Berkowitz and Santos, {Jos{\'e} L.} and Borzone, {Gisella R.} and Poblete, {Jos{\'e} A.} and Claudio Vera and Cristi{\'a}n Belmar and Denisse Goldenberg and B{\'a}rbara Samith and Acosta, {Ana M.} and Manuel Escalona and Ian Niklitschek and Mandiola, {Jorge R.} and Nicol{\'a}s Mertens",

note = "Publisher Copyright: {\textcopyright} 2014 The Obesity Society. 2014.",

year = "2014",

month = oct,

day = "1",

doi = "10.1002/oby.20816",

language = "English",

volume = "22",

pages = "2156--2163",

journal = "Obesity",

issn = "1930-7381",

publisher = "John Wiley and Sons Inc.",

number = "10",

}

Olmos, PR, Rigotti, A, Busso, D, Berkowitz, L, Santos, JL, Borzone, GR, Poblete, JA, Vera, C, Belmar, C, Goldenberg, D, Samith, B, Acosta, AM, Escalona, M, Niklitschek, I, Mandiola, JR & Mertens, N 2014, 'Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes', Obesity, vol. 22, no. 10, pp. 2156-2163. https://doi.org/10.1002/oby.20816

TY - JOUR

T1 - Maternal hypertriglyceridemia

T2 - A link between maternal overweight-obesity and macrosomia in gestational diabetes

AU - Olmos, Pablo R.

AU - Rigotti, Attilio

AU - Busso, Dolores

AU - Berkowitz, Loni

AU - Santos, José L.

AU - Borzone, Gisella R.

AU - Poblete, José A.

AU - Vera, Claudio

AU - Belmar, Cristián

AU - Goldenberg, Denisse

AU - Samith, Bárbara

AU - Acosta, Ana M.

AU - Escalona, Manuel

AU - Niklitschek, Ian

AU - Mandiola, Jorge R.

AU - Mertens, Nicolás

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

AB - Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.

KW - Adult

KW - Body Weight

KW - Diabetes

KW - Gestational

KW - Female

KW - Fetal Macrosomia

KW - Gestational Age

KW - Humans

KW - Hypertriglyceridemia

KW - Infant

KW - Newborn

KW - Obesity

KW - Pregnancy

KW - Pregnancy Complications

KW - Prospective Studies

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U2 - 10.1002/oby.20816

DO - 10.1002/oby.20816

M3 - Article

C2 - 24957884

AN - SCOPUS:84907662729

SN - 1930-7381

VL - 22

SP - 2156

EP - 2163

JO - Obesity

JF - Obesity

IS - 10

ER -

Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Abstract

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