Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos, Attilio Rigotti, Dolores Busso, Loni Berkowitz, José L. Santos, Gisella R. Borzone, José A. Poblete, Claudio Vera, Cristián Belmar, Denisse Goldenberg, Bárbara Samith, Ana M. Acosta, Manuel Escalona, Ian Niklitschek, Jorge R. Mandiola, Nicolás Mertens

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

2014. Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.
Original languageAmerican English
Pages (from-to)2156-2163
Number of pages8
JournalObesity
Volume22
Issue number10
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

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