Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy

Jorge Bartolucci, Fernando J. Verdugo, Flavio Carrion, Ema Abarzúa, Carlos Goset, Rubén Lamich, Patricio Sanhueza, Pablo Pedreros, Carolina Nazzal, Maroun Khoury, Fernando Figueroa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Intracoronary delivery of autologous bone marrow mononuclear cells is an interesting therapeutic promise for patients with heart failure of different etiologies. Aim: To evaluate the long-term safety and efficacy of this therapy in patients with dilated cardiomyopathy of different etiologies under optimal medical treatment. Patients and Methods: Prospective, open-label, controlled clinical trial. Of 23 consecutive patients, 12 were assigned to autologous bone marrow mononuclear cell intracoronary transplantation, receiving a mean dose of 8.19 ± 4.43 x 106 CD34+ cells. Mortality, cardiovascular readmissions and cancer incidence rate, changes in functional capacity, quality of life questionnaires and echocardiographic measures from baseline, were assessed at long-term follow-up (37.7 ± 9.7 months) in patients receiving or not the cells. Results: No significant differences were observed in mortality, cardiovascular readmissions or cancer incidence rate amongst groups. An improvement in functional class and quality of life questionnaires in the transplanted group was observed (p < 0.01). The treated group showed a non-significant increase in left ventricular ejection fraction at long-term follow-up (from 26.75 ± 4.85% to 34.90 ± 8.57%, p = 0.059 compared to baseline). There were no changes in left ventricular volumes. We observed no improvement of these variables in the control group. Conclusions: Intracoronary transplantation of autologous bone marrow mononuclear cells is feasible and safe in patients with dilated cardiomyopathy of diverse etiologies. This therapy was associated to persistent improvements in functional class and quality of life. There was also a non-significant long-term improvement of left ventricular function.

Translated title of the contributionLong-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy
Original languageSpanish
Pages (from-to)415-423
Number of pages9
JournalRevista Medica de Chile
Volume143
Issue number4
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015, Sociedad Medica de Santiago. All rights reserved.

Fingerprint Dive into the research topics of 'Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy'. Together they form a unique fingerprint.

Cite this