Leucocyte- and platelet-rich fibrin block for bone augmentation procedure: A proof-of-concept study

Simone Cortellini*, Ana B. Castro, Andy Temmerman, Jeroen Van Dessel, Nelson Pinto, Reinhilde Jacobs, Marc Quirynen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Aim: The objective of this proof-of-concept study was to investigate the effects of a new guided bone regeneration technique with a tissue engineering approach. Materials and Methods: This single cohort observational study evaluated the outcome of the leucocyte- and platelet-rich fibrin (L-PRF) Block for horizontal bone augmentation in the maxilla. The L-PRF Block is prepared by mixing a particulated biomaterial with chopped L-PRF membranes at a 50:50 ratio and adding liquid fibrinogen to glue all together. Horizontal augmentation was assessed linearly and volumetrically immediately after surgery and 5–8 months later by matching consecutive cone beam computed tomography (CBCTs). Results: Ten patients (mean age of 50.7 years [±17.2]) representing 15 sites with horizontal alveolar deficiencies were included. Superimposition of pre-operative and posthealing CBCT scans showed an average linear horizontal bone gain of 4.6 mm (±2.3), 5.3 mm (±1.2) and 4.4 mm (±2.3), measured at 2, 6 and 10 mm from the alveolar crest, respectively. The volumetric gain was 1.05 cm3 (±0.7) on average. The resorption rate after 5–8 months was 15.6% (±6.7) on average. Conclusions: L-PRF Block may be a suitable technique to augment deficient alveolar ridges.

Original languageEnglish
Pages (from-to)624-634
Number of pages11
JournalJournal of Clinical Periodontology
Issue number5
StatePublished - May 2018

Bibliographical note

Funding Information:
The Section of Periodontology (KU Leuven) received unrestricted research grants from GC Europe N.V. (chair in bioregeneration) and Intra-Lock International Inc. (chair in optimized osseointegration). Jeroen Van Dessel is a researcher supported by Research Foundation Flanders (FWO).

Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • bone augmentation
  • bone substitutes
  • bone volume
  • guided bone regeneration
  • leucocyte- and platelet-rich fibrin
  • leucocyte- and platelet-rich fibrin block
  • platelet concentrate
  • tissue engineering


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