Leflunomide as a cause of collagenous colitis: An entity to consider

Paulina Núñez, Rodrigo Quera, Lilian Flores, Luis Contreras

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


Leflunomide belongs in the group of disease-modifying anti-rheumatic drugs (DMARDs) used in the treatment of psoriatic, rheumatoid, and reactive arthritis. Approximately 20 % of patients will experience some adverse event, mainly weight loss, abdominal pain, and diarrhea. We describe the clinical, endoscopic, and histological findings in a patient with psoriatic arthritis (PA) who developed severe chronic diarrhea after drug use.

Original languageEnglish
Pages (from-to)735-736
Number of pages2
JournalRevista Espanola de Enfermedades Digestivas
Issue number10
StatePublished - Oct 2021


  • Chronic diarrhea
  • Collagenous colitis
  • Leflunomide


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