Laboratory surveillance for invasive meningococcal disease in Chile, 2006-2012

Pamela Araya, Janepsy Díaz, Mabel Seoane, Jorge Fernández, Solana Terrazas, Andrea Canals, Alejandra Vaquero, Gisselle Barra, Juan C. Hormazábal, Paola Pidal, M. Teresa Valenzuela

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

All rights reserved. Background: Laboratory surveillance of Invasive Meningococcal Disease (IMD) is performed by the Institute of Public Health of Chile. It confrms identifcation, classifes in serogroups and analyzes the genetic profles of Neisseria meningitidis isolates from laboratories throughout the country. Aim: To show the results of this surveillance from 2006 to 2012. Methods: A descriptive data analysis of the confrmed cases of IMD and serological characterization, susceptibility and genetic profles of the isolates. The analysis was disaggregated by serogroup, age and region. Results: From 2006 to 2012, 486 isolates of N. meningitidis were confrmed. In 2011 a rise in IMD rates was observed due to an increase in W serogroup cases, mainly affecting children aged 5 years or less. Serogroup W became the most prevalent during 2012 (58.3%), replacing the historically prevalent serogroup B. Predominating strains belonged to ST-32 complex/ET-5 complex (40, 4% of strains) and ST-41/44 complex/ Lineage 3 (45, 9% of strains). Conclusions: Laboratory surveillance has allowed the early detection of increasing IMD caused by serogroup W, which is emergent in Chile. This information has reinforced the daily monitoring of new cases, in collaboration with all the clinical laboratories of the country.
Original languageAmerican English
Pages (from-to)377-384
Number of pages8
JournalRevista Chilena de Infectologia
Volume31
Issue number4
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Meningococcal invasive disease
  • Neisseria meningitidis
  • Serogroup W
  • Surveillance

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