Précis - The art and science of oro-maxillo-facial reconstruction is of great interest for contemporary oral and maxillofacial surgeons; in search for better bioengineering strategies and biomaterials: a core driver for bio-dental research, today. Leukocyteand Platelet-Rich Fibrin (L-PRF) is a 3-D autogenous biomaterial obtained via the simple and rapid centrifugation of whole blood patient samples, in the absence of anti-coagulants, bovine thrombin, additives or any gelifying agents. A relatively new “revolutionary” step in 2nd generation platelet concentrate-based therapeutics, the clinical safety, and more so, efficacy and effectiveness of L-PRF remains highly debatable, whether due to significant variabilities in preparation protocols, limited evidence-based scientific and clinical literature and/or inadequate
Bibliographical noteFunding Information:
Acknowledgements: This work was carried out under onging collaboration between Universidad de los Andes and Lebanese University; supported by operating grants provided to BioMAT’X (Laboratorio de Biomateriales, Farmacéuticos y Bioingeniería de Tejidos Cráneo Máxilo-Facial), member of CIIB (Centro de Investigación e Innovación Biomédica), through the Faculty of Dentistry and PMI (Danilo Segovia, Anil Sadarangani and Silvana Becerra) Univ. los Andes, Santiago de Chile and CONICYT-FONDEF (Grant ID# 16I10366).