Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.

Karl Heinz Smalla; Constanze I. Seidenbecher; Wolfgang Tischmeyer; Horst Schicknick; Ursula Wyneken; Tobias M. Böckers; Eckart D. Gundelfinger; Michael R. Kreutz

doi:10.1016/S0169-328X(03)00235-3

Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.

Karl Heinz Smalla, Constanze I. Seidenbecher, Wolfgang Tischmeyer, Horst Schicknick, Ursula Wyneken, Tobias M. Böckers, Eckart D. Gundelfinger, Michael R. Kreutz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Caldendrin defines a novel family of neuronal calcium-sensor proteins, the C-terminal moiety of which displays high similarity to calmodulin. We now report that the protein is recruited to the postsynaptic density (PSD) of cortical and hippocampal neurons in response to kainate-induced epileptic seizures, an animal model of human temporal lobe epilepsy. The translocation of caldendrin to the PSD did not occur in kainate-treated rats that did not develop seizures. The enhanced PSD levels of caldendrin are not due to increased protein synthesis and most likely reflect a recruitment from the soluble caldendrin protein pool. These findings suggest that the transduction of dendritic Ca²⁺-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Molecular Brain Research
Volume	116
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(03)00235-3
State	Published - 19 Aug 2003

Bibliographical note

Funding Information:
The authors gratefully acknowledge the professional technical assistance of C. Borutzki and M. Marunde. Supported by the DFG (Kr1879/2-1, 2-2), the Volkswagen Foundation, the Fonds der Chemischen Industrie and the Land Sachsen-Anhalt (FKZ: 2508A/0086; 3004A/0088H).

Keywords

Cytoskeleton
EF-hand protein
Seizures
Synapse
Temporal lobe epilepsy

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10.1016/S0169-328X(03)00235-3

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title = "Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.",

abstract = "Caldendrin defines a novel family of neuronal calcium-sensor proteins, the C-terminal moiety of which displays high similarity to calmodulin. We now report that the protein is recruited to the postsynaptic density (PSD) of cortical and hippocampal neurons in response to kainate-induced epileptic seizures, an animal model of human temporal lobe epilepsy. The translocation of caldendrin to the PSD did not occur in kainate-treated rats that did not develop seizures. The enhanced PSD levels of caldendrin are not due to increased protein synthesis and most likely reflect a recruitment from the soluble caldendrin protein pool. These findings suggest that the transduction of dendritic Ca2+-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy.",

keywords = "Cytoskeleton, EF-hand protein, Seizures, Synapse, Temporal lobe epilepsy",

author = "Smalla, {Karl Heinz} and Seidenbecher, {Constanze I.} and Wolfgang Tischmeyer and Horst Schicknick and Ursula Wyneken and B{\"o}ckers, {Tobias M.} and Gundelfinger, {Eckart D.} and Kreutz, {Michael R.}",

note = "Funding Information: The authors gratefully acknowledge the professional technical assistance of C. Borutzki and M. Marunde. Supported by the DFG (Kr1879/2-1, 2-2), the Volkswagen Foundation, the Fonds der Chemischen Industrie and the Land Sachsen-Anhalt (FKZ: 2508A/0086; 3004A/0088H).",

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doi = "10.1016/S0169-328X(03)00235-3",

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AU - Smalla, Karl Heinz

AU - Seidenbecher, Constanze I.

AU - Tischmeyer, Wolfgang

AU - Schicknick, Horst

AU - Wyneken, Ursula

AU - Böckers, Tobias M.

AU - Gundelfinger, Eckart D.

AU - Kreutz, Michael R.

N1 - Funding Information: The authors gratefully acknowledge the professional technical assistance of C. Borutzki and M. Marunde. Supported by the DFG (Kr1879/2-1, 2-2), the Volkswagen Foundation, the Fonds der Chemischen Industrie and the Land Sachsen-Anhalt (FKZ: 2508A/0086; 3004A/0088H).

PY - 2003/8/19

Y1 - 2003/8/19

N2 - Caldendrin defines a novel family of neuronal calcium-sensor proteins, the C-terminal moiety of which displays high similarity to calmodulin. We now report that the protein is recruited to the postsynaptic density (PSD) of cortical and hippocampal neurons in response to kainate-induced epileptic seizures, an animal model of human temporal lobe epilepsy. The translocation of caldendrin to the PSD did not occur in kainate-treated rats that did not develop seizures. The enhanced PSD levels of caldendrin are not due to increased protein synthesis and most likely reflect a recruitment from the soluble caldendrin protein pool. These findings suggest that the transduction of dendritic Ca2+-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy.

AB - Caldendrin defines a novel family of neuronal calcium-sensor proteins, the C-terminal moiety of which displays high similarity to calmodulin. We now report that the protein is recruited to the postsynaptic density (PSD) of cortical and hippocampal neurons in response to kainate-induced epileptic seizures, an animal model of human temporal lobe epilepsy. The translocation of caldendrin to the PSD did not occur in kainate-treated rats that did not develop seizures. The enhanced PSD levels of caldendrin are not due to increased protein synthesis and most likely reflect a recruitment from the soluble caldendrin protein pool. These findings suggest that the transduction of dendritic Ca2+-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy.

KW - Cytoskeleton

KW - EF-hand protein

KW - Seizures

KW - Synapse

KW - Temporal lobe epilepsy

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AN - SCOPUS:0041519059

SN - 0169-328X

VL - 116

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JF - Molecular Brain Research

IS - 1-2

ER -

Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.

Abstract

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Keywords

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