Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: An exploratory genotype-environment interaction study

Luis A. Quiñones, Carlos E. Irarrázabal, Claudio R. Rojas, Cristian E. Orellana, Cristian Acevedo, Christian Huidobro, Nelson E. Varela, Dante D. Cáceres

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. Methods: In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. Results: The joint risk for smokers carrying Pro* and M1*, Pro* and GSTM1 null or GSTM1 null and CYP1A1 M1* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71). Conclusion: Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.
Original languageAmerican English
Pages (from-to)349-355
Number of pages7
JournalAsian Journal of Andrology
Volume8
Issue number3
DOIs
StatePublished - 1 May 2006
Externally publishedYes

Keywords

  • CYP1A1
  • Genetic polymorphism
  • GSTM1
  • p53cd72
  • Prostate cancer
  • Risk
  • Smoking

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