Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes

Roberto Romero; Ruben Quintero; Enrique Oyarzun; Ying King Wu; Virginia Sabo; Moshe Mazor; John C. Hobbins

doi:10.1016/S0002-9378(88)80030-9

Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes

Roberto Romero^*, Ruben Quintero, Enrique Oyarzun, Ying King Wu, Virginia Sabo, Moshe Mazor, John C. Hobbins

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

321 Scopus citations

Abstract

The purpose of this study was to examine the relationship between intraamniotic infection and the onset of labor in patients with preterm premature rupture of the membranes. Two hundred and thirty consecutive patients were admitted with premature rupture of the membranes to Yale-New Haven Hospital from January 1985 to July 1987. Amniotic fluid was retrieved by amniocentesis from 96% (221/230). Sixty-one patients were in labor on admission (27.6%, 61/221) and 39% of them (24/61) had a positive amniotic fluid culture. Patients in labor on admission were more likely to have a positive amniotic fluid culture than those who were not in labor on admission (24/61 versus 41/160, p = 0.049). Of the 160 patients who were not in labor on admission, 81 subsequently went into spontaneous labor; microbiologic information at the time of labor was known in 48 of these patients (59.2%). Seventy-five percent (36/48) of these patients had a positive amniotic fluid culture. The incidence of intraamniotic infection in quiescent women who subsequently went into labor was higher than that of patients admitted in active labor (75% versus 39%, p = 0.0004). These results provide a basis for the clinical impression that the onset of labor in women with preterm premature rupture of the membranes is associated with a subdinical intraamniotic infection. The mechanisms responsible for the onset of labor in women without an intraamniotic infection may be associated with an extraamniotic infection (e.g., deciduitis) or a noninfectious process. (AM J

Original language	English
Pages (from-to)	661-666
Number of pages	6
Journal	American Journal of Obstetrics and Gynecology
Volume	159
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9378(88)80030-9
State	Published - 1988
Externally published	Yes

Bibliographical note

Funding Information:
From the Department of Obstetrics and Gynecology, Yale University School of Medicine. Supported by a grant from the Walter Scott Foundation for Medical Research. Dr. Romero is a recipient of a Physician Scientist Award from the National Institutes of Health. Presented at the Eighth Annual Meeting of the Society of Perinatal Obstetricians, Las Vegas, Nevada, February 4-6, 1988. Reprint requests: Roberto Romero, MD, Yale University School of Medicine, Department of Obstetrics and Gynecology, P.O. Box 3333, New Haven, CT 06510.

Keywords

Intraamniotic infection
parturition
premature rupture of the membranes
prematurity
preterm labor

Access to Document

10.1016/S0002-9378(88)80030-9

Cite this

@article{ade0ac2710b24ac1bc766bca58a1a415,

title = "Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes",

abstract = "The purpose of this study was to examine the relationship between intraamniotic infection and the onset of labor in patients with preterm premature rupture of the membranes. Two hundred and thirty consecutive patients were admitted with premature rupture of the membranes to Yale-New Haven Hospital from January 1985 to July 1987. Amniotic fluid was retrieved by amniocentesis from 96% (221/230). Sixty-one patients were in labor on admission (27.6%, 61/221) and 39% of them (24/61) had a positive amniotic fluid culture. Patients in labor on admission were more likely to have a positive amniotic fluid culture than those who were not in labor on admission (24/61 versus 41/160, p = 0.049). Of the 160 patients who were not in labor on admission, 81 subsequently went into spontaneous labor; microbiologic information at the time of labor was known in 48 of these patients (59.2%). Seventy-five percent (36/48) of these patients had a positive amniotic fluid culture. The incidence of intraamniotic infection in quiescent women who subsequently went into labor was higher than that of patients admitted in active labor (75% versus 39%, p = 0.0004). These results provide a basis for the clinical impression that the onset of labor in women with preterm premature rupture of the membranes is associated with a subdinical intraamniotic infection. The mechanisms responsible for the onset of labor in women without an intraamniotic infection may be associated with an extraamniotic infection (e.g., deciduitis) or a noninfectious process. (AM J",

keywords = "Intraamniotic infection, parturition, premature rupture of the membranes, prematurity, preterm labor",

author = "Roberto Romero and Ruben Quintero and Enrique Oyarzun and Wu, {Ying King} and Virginia Sabo and Moshe Mazor and Hobbins, {John C.}",

note = "Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine. Supported by a grant from the Walter Scott Foundation for Medical Research. Dr. Romero is a recipient of a Physician Scientist Award from the National Institutes of Health. Presented at the Eighth Annual Meeting of the Society of Perinatal Obstetricians, Las Vegas, Nevada, February 4-6, 1988. Reprint requests: Roberto Romero, MD, Yale University School of Medicine, Department of Obstetrics and Gynecology, P.O. Box 3333, New Haven, CT 06510.",

year = "1988",

doi = "10.1016/S0002-9378(88)80030-9",

language = "English",

volume = "159",

pages = "661--666",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes

AU - Romero, Roberto

AU - Quintero, Ruben

AU - Oyarzun, Enrique

AU - Wu, Ying King

AU - Sabo, Virginia

AU - Mazor, Moshe

AU - Hobbins, John C.

N1 - Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine. Supported by a grant from the Walter Scott Foundation for Medical Research. Dr. Romero is a recipient of a Physician Scientist Award from the National Institutes of Health. Presented at the Eighth Annual Meeting of the Society of Perinatal Obstetricians, Las Vegas, Nevada, February 4-6, 1988. Reprint requests: Roberto Romero, MD, Yale University School of Medicine, Department of Obstetrics and Gynecology, P.O. Box 3333, New Haven, CT 06510.

PY - 1988

Y1 - 1988

N2 - The purpose of this study was to examine the relationship between intraamniotic infection and the onset of labor in patients with preterm premature rupture of the membranes. Two hundred and thirty consecutive patients were admitted with premature rupture of the membranes to Yale-New Haven Hospital from January 1985 to July 1987. Amniotic fluid was retrieved by amniocentesis from 96% (221/230). Sixty-one patients were in labor on admission (27.6%, 61/221) and 39% of them (24/61) had a positive amniotic fluid culture. Patients in labor on admission were more likely to have a positive amniotic fluid culture than those who were not in labor on admission (24/61 versus 41/160, p = 0.049). Of the 160 patients who were not in labor on admission, 81 subsequently went into spontaneous labor; microbiologic information at the time of labor was known in 48 of these patients (59.2%). Seventy-five percent (36/48) of these patients had a positive amniotic fluid culture. The incidence of intraamniotic infection in quiescent women who subsequently went into labor was higher than that of patients admitted in active labor (75% versus 39%, p = 0.0004). These results provide a basis for the clinical impression that the onset of labor in women with preterm premature rupture of the membranes is associated with a subdinical intraamniotic infection. The mechanisms responsible for the onset of labor in women without an intraamniotic infection may be associated with an extraamniotic infection (e.g., deciduitis) or a noninfectious process. (AM J

AB - The purpose of this study was to examine the relationship between intraamniotic infection and the onset of labor in patients with preterm premature rupture of the membranes. Two hundred and thirty consecutive patients were admitted with premature rupture of the membranes to Yale-New Haven Hospital from January 1985 to July 1987. Amniotic fluid was retrieved by amniocentesis from 96% (221/230). Sixty-one patients were in labor on admission (27.6%, 61/221) and 39% of them (24/61) had a positive amniotic fluid culture. Patients in labor on admission were more likely to have a positive amniotic fluid culture than those who were not in labor on admission (24/61 versus 41/160, p = 0.049). Of the 160 patients who were not in labor on admission, 81 subsequently went into spontaneous labor; microbiologic information at the time of labor was known in 48 of these patients (59.2%). Seventy-five percent (36/48) of these patients had a positive amniotic fluid culture. The incidence of intraamniotic infection in quiescent women who subsequently went into labor was higher than that of patients admitted in active labor (75% versus 39%, p = 0.0004). These results provide a basis for the clinical impression that the onset of labor in women with preterm premature rupture of the membranes is associated with a subdinical intraamniotic infection. The mechanisms responsible for the onset of labor in women without an intraamniotic infection may be associated with an extraamniotic infection (e.g., deciduitis) or a noninfectious process. (AM J

KW - Intraamniotic infection

KW - parturition

KW - premature rupture of the membranes

KW - prematurity

KW - preterm labor

UR - http://www.scopus.com/inward/record.url?scp=0023686301&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(88)80030-9

DO - 10.1016/S0002-9378(88)80030-9

M3 - Article

C2 - 3421266

AN - SCOPUS:0023686301

SN - 0002-9378

VL - 159

SP - 661

EP - 666

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 3

ER -

Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this