Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

Yang Xu; Jan Philipp Weltzsch; Christoph Kilian; Babett Steglich; Christina Weiler-Normann; Michael Dudek; Jonas Fackler; Malte H. Wehmeyer; Joseph Tintelnot; Laura A. Liebig; Silja Steinmann; Alena Laschtowitz; Ludwig J. Horst; Ida Schregel; Marcial Sebode; Johannes Hartl; Christian Casar; Jing Lu; Gerhard Schön; Antonia Zapf; Maria Rosa Bono; Mariana V. Rosemblatt; Sarah Nuñez; Justine Castañeda; Sören Alexander Weidemann; Nico Kaiser; Maria Schwerk; Manuela Kolster; Guido Rattay; Hanna Ulrich; Varshi Sivayoganathan; Ning Song; Jenny Krause; Marius Böttcher; Adrian Sagebiel; Jonas Wagner; Christian F. Krebs; Victor G. Puelles; Norbert Hübner; Eva Tolosa; Stefan Bonn; Samuel Huber; Percy A. Knolle; Johannes Herkel; Lorenz Adlung; Christoph Schramm; Nicola Gagliani; Ansgar Wilhelm Lohse

doi:10.1016/j.jhep.2026.02.026

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

Yang Xu
, Jan Philipp Weltzsch
, Christoph Kilian
, Babett Steglich
, Christina Weiler-Normann
, Michael Dudek
, Jonas Fackler
, Malte H. Wehmeyer
, Joseph Tintelnot
, Laura A. Liebig
, Silja Steinmann
, Alena Laschtowitz
, Ludwig J. Horst
, Ida Schregel
, Marcial Sebode
, Johannes Hartl
, Christian Casar
, Jing Lu
, Gerhard Schön
, Antonia Zapf

Maria Rosa Bono, Mariana V. Rosemblatt, Sarah Nuñez, Justine Castañeda, Sören Alexander Weidemann, Nico Kaiser, Maria Schwerk, Manuela Kolster, Guido Rattay, Hanna Ulrich, Varshi Sivayoganathan, Ning Song, Jenny Krause, Marius Böttcher, Adrian Sagebiel, Jonas Wagner, Christian F. Krebs, Victor G. Puelles, Norbert Hübner, Eva Tolosa, Stefan Bonn, Samuel Huber, Percy A. Knolle, Johannes Herkel, Lorenz Adlung, Christoph Schramm, Nicola Gagliani, Ansgar Wilhelm Lohse

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	71
Number of pages	90
Journal	Journal of Hepatology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/j.jhep.2026.02.026
State	Published - Jul 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jhep.2026.02.026

Cite this

Xu, Y., Weltzsch, J. P., Kilian, C., Steglich, B., Weiler-Normann, C., Dudek, M., Fackler, J., Wehmeyer, M. H., Tintelnot, J., Liebig, L. A., Steinmann, S., Laschtowitz, A., Horst, L. J., Schregel, I., Sebode, M., Hartl, J., Casar, C., Lu, J., Schön, G., ... Lohse, A. W. (2026). Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis. Journal of Hepatology, 85(1), 71. https://doi.org/10.1016/j.jhep.2026.02.026

@article{bb061739c65342ffa5589622fac4c723,

title = "Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis",

author = "Yang Xu and Weltzsch, \{Jan Philipp\} and Christoph Kilian and Babett Steglich and Christina Weiler-Normann and Michael Dudek and Jonas Fackler and Wehmeyer, \{Malte H.\} and Joseph Tintelnot and Liebig, \{Laura A.\} and Silja Steinmann and Alena Laschtowitz and Horst, \{Ludwig J.\} and Ida Schregel and Marcial Sebode and Johannes Hartl and Christian Casar and Jing Lu and Gerhard Sch{\"o}n and Antonia Zapf and Bono, \{Maria Rosa\} and Rosemblatt, \{Mariana V.\} and Sarah Nu{\~n}ez and Justine Casta{\~n}eda and Weidemann, \{S{\"o}ren Alexander\} and Nico Kaiser and Maria Schwerk and Manuela Kolster and Guido Rattay and Hanna Ulrich and Varshi Sivayoganathan and Ning Song and Jenny Krause and Marius B{\"o}ttcher and Adrian Sagebiel and Jonas Wagner and Krebs, \{Christian F.\} and Puelles, \{Victor G.\} and Norbert H{\"u}bner and Eva Tolosa and Stefan Bonn and Samuel Huber and Knolle, \{Percy A.\} and Johannes Herkel and Lorenz Adlung and Christoph Schramm and Nicola Gagliani and Lohse, \{Ansgar Wilhelm\}",

year = "2026",

month = jul,

doi = "10.1016/j.jhep.2026.02.026",

language = "English",

volume = "85",

pages = "71",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "1",

}

Xu, Y, Weltzsch, JP, Kilian, C, Steglich, B, Weiler-Normann, C, Dudek, M, Fackler, J, Wehmeyer, MH, Tintelnot, J, Liebig, LA, Steinmann, S, Laschtowitz, A, Horst, LJ, Schregel, I, Sebode, M, Hartl, J, Casar, C, Lu, J, Schön, G, Zapf, A, Bono, MR, Rosemblatt, MV, Nuñez, S, Castañeda, J, Weidemann, SA, Kaiser, N, Schwerk, M, Kolster, M, Rattay, G, Ulrich, H, Sivayoganathan, V, Song, N, Krause, J, Böttcher, M, Sagebiel, A, Wagner, J, Krebs, CF, Puelles, VG, Hübner, N, Tolosa, E, Bonn, S, Huber, S, Knolle, PA, Herkel, J, Adlung, L, Schramm, C, Gagliani, N & Lohse, AW 2026, 'Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis', Journal of Hepatology, vol. 85, no. 1, pp. 71. https://doi.org/10.1016/j.jhep.2026.02.026

TY - JOUR

T1 - Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

AU - Xu, Yang

AU - Weltzsch, Jan Philipp

AU - Kilian, Christoph

AU - Steglich, Babett

AU - Weiler-Normann, Christina

AU - Dudek, Michael

AU - Fackler, Jonas

AU - Wehmeyer, Malte H.

AU - Tintelnot, Joseph

AU - Liebig, Laura A.

AU - Steinmann, Silja

AU - Laschtowitz, Alena

AU - Horst, Ludwig J.

AU - Schregel, Ida

AU - Sebode, Marcial

AU - Hartl, Johannes

AU - Casar, Christian

AU - Lu, Jing

AU - Schön, Gerhard

AU - Zapf, Antonia

AU - Bono, Maria Rosa

AU - Rosemblatt, Mariana V.

AU - Nuñez, Sarah

AU - Castañeda, Justine

AU - Weidemann, Sören Alexander

AU - Kaiser, Nico

AU - Schwerk, Maria

AU - Kolster, Manuela

AU - Rattay, Guido

AU - Ulrich, Hanna

AU - Sivayoganathan, Varshi

AU - Song, Ning

AU - Krause, Jenny

AU - Böttcher, Marius

AU - Sagebiel, Adrian

AU - Wagner, Jonas

AU - Krebs, Christian F.

AU - Puelles, Victor G.

AU - Hübner, Norbert

AU - Tolosa, Eva

AU - Bonn, Stefan

AU - Huber, Samuel

AU - Knolle, Percy A.

AU - Herkel, Johannes

AU - Adlung, Lorenz

AU - Schramm, Christoph

AU - Gagliani, Nicola

AU - Lohse, Ansgar Wilhelm

PY - 2026/7

Y1 - 2026/7

UR - http://dx.doi.org/10.1016/j.jhep.2026.02.026

U2 - 10.1016/j.jhep.2026.02.026

DO - 10.1016/j.jhep.2026.02.026

M3 - Article

SN - 0168-8278

VL - 85

SP - 71

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 1

ER -

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

UN SDGs

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