Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis

Chama Belkhiria, Rodrigo C. Vergara, Simón San Martin, Alexis Leiva, Melissa Martinez, Bruno Marcenaro, Maricarmen Andrade, Paul H. Delano, Carolina Delgado

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3 Scopus citations

Abstract

Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or presbycusis. One hundred eleven independent, non-demented subjects older than 65 years recruited in the ANDES cohort were evaluated using a combined approach including (i) audiological tests: hearing thresholds and cochlear function measured by pure tone averages and the distortion product otoacoustic emissions respectively; (ii) behavioral variables: cognitive, neuropsychiatric, and functional impairment in activities of daily living measured by validated questionnaires; and (iii) structural brain imaging—assessed by magnetic resonance imaging at 3 Tesla. The mean age of the recruited subjects (69 females) was 73.95 ± 5.47 years (mean ± SD) with an average educational level of 9.44 ± 4.2 years of schooling. According to the audiometric hearing thresholds and presence of otoacoustic emissions, we studied three groups: controls with normal hearing (n = 36), presbycusis with preserved cochlear function (n = 33), and presbycusis with cochlear dysfunction (n = 38). We found a significant association (R2D = 0.17) between the number of detected otoacoustic emissions and apathy symptoms. The presbycusis with cochlear dysfunction group had worse performance than controls in global cognition, language and executive functions, and severe apathy symptoms than the other groups. The neuropsychiatric symptoms and language deficits were the main determinants of functional impairment in both groups of subjects with presbycusis. Atrophy of insula, amygdala, and other temporal areas were related with functional impairment, apathy, and language deficits in the presbycusis with cochlear dysfunction group. We conclude that (i) the neuropsychiatric symptoms had a major effect on functional loss in subjects with presbycusis, (ii) cochlear dysfunction is relevant for the association between hearing loss and behavioral impairment, and (iii) atrophy of the insula and amygdala among other temporal areas are related with hearing loss and behavioral impairment.

Original languageEnglish
Article number102
JournalFrontiers in Aging Neuroscience
Volume12
DOIs
StatePublished - 28 Apr 2020

Bibliographical note

Funding Information:
This project was funded by Fondecyt 1161155 to PD, Proyecto Anillo ACT1403, CONICYT BASAL FB008, Proyecto ICM P09-015F, and Fundación Guillermo Puelma.

Funding Information:
We would like to thank the participants that gave their time to take part in this study and everybody who has contributed to its realization. Funding. This project was funded by Fondecyt 1161155 to PD, Proyecto Anillo ACT1403, CONICYT BASAL FB008, Proyecto ICM P09-015F, and Fundaci?n Guillermo Puelma.

Publisher Copyright:
© Copyright © 2020 Belkhiria, Vergara, San Martin, Leiva, Martinez, Marcenaro, Andrade, Delano and Delgado.

Keywords

  • activities of daily living
  • apathy
  • behavioral impairment
  • cochlear dysfunction
  • dementia
  • insula atrophy
  • presbycusis

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