Instructions for the use of L-PRF in different clinical indications

M. Quirynen*, J. Blanco, H. L. Wang, N. Donos, A. Temmerman, A. Castro, N. Pinto

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Autologous platelet concentrates (APCs) have demonstrated clear benefits across various clinical applications, including alveolar ridge preservation, guided tissue regeneration, guided bone regeneration, sinus floor elevation (both lateral window approach and transcrestal technique), endodontic surgery, the treatment of medication-related osteonecrosis of the jaw bones, and periodontal plastic surgery. To ensure an optimal clinical outcome, clinicians must adhere strictly to the protocol to prepare the APCs and, especially follow evidence-based surgical guidelines, often simple but crucial, to minimize the likelihood of errors. The majority of clinical trials reported on second-generation APCs [the leukocyte- and platelet-rich fibrin (L-PRF) family, including its modifications (A-PRF, A-PRF+, CGF, T-PRF, H-PRF, etc.)]. These second-generation APCs offer additional benefits compared to the first-generation APCs, making them the preferred choice for the development of clinical recommendations. These recommendations have been formulated through a meticulous examination of the available clinical data and the clinical experience of the authors of this paper.

Original languageEnglish
JournalPeriodontology 2000
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.


  • alveolar ridge preservation
  • autologous platelet concentrates
  • flowcharts
  • guided bone regeneration
  • guided tissue regeneration
  • intra-bony defects
  • medication-related osteonecrosis of the jaw bones
  • plastic periodontal surgery
  • sinus floor elevation (lateral window technique, transcrestal technique)


Dive into the research topics of 'Instructions for the use of L-PRF in different clinical indications'. Together they form a unique fingerprint.

Cite this