Abstract
Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an endocrine factor. The observation that changes in skeletal muscle glucose metabolism are accompanied by altered insulin secretion supports this hypothesis. Meanwhile, a muscle-derived circulating factor affecting in vivo insulin secretion remains elusive. This factor may correspond to peptides/proteins (so called myokines), exosomes and their cargo, and metabolites. We hereby review the most remarkable evidence encouraging the possibility of such inter-organ communication, with special focus on muscle-derived factors that may potentially mediate such skeletal muscle-pancreas crosstalk.
Original language | English |
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Article number | 1024 |
Journal | Frontiers in Physiology |
Volume | 10 |
Issue number | AUG |
DOIs | |
State | Published - 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Mizgier, Fernández-Verdejo, Cherfan, Pinget, Bouzakri and Galgani.
Keywords
- Beta cell
- Crosstalk
- Exosomes
- Insulin secretion
- Insulin sensitivity
- MiRNA
- Muscle
- Myokines