Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study

Cristina Saldivia-Siracusa, Anna Luíza Damaceno Araújo, Lady Paola Aristizabal Arboleda, Thamiris Abrantes, Mariana Bitu Ramos Pinto, Nathalia Mendonça, Karina Cordero-Torres, Gerardo Gilligan, Eduardo Piemonte, Rene Panico, Fábio De-Abreu-álves, Mariana Villaroel-Dorrego, Mário José Romañach, Aline Corrêa Abrahão, Wilfredo Alejandro González-Arriagada, Keith D. Hunter, Ana Carolina Prado Ribeiro, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: To describe demographic and clinicopathological aspects of a South-American cohort of incipient oral squamous cell carcinoma patients. Material and Methods: A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South-American institutions. Results: One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in-situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), ≥ 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red. Conclusions: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians’ inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.

Original languageEnglish
Article number26551
Pages (from-to)e575-e583
Number of pages9
JournalMedicina Oral Patologia Oral y Cirugia Bucal
Volume29
Issue number4
DOIs
StatePublished - Jul 2024

Bibliographical note

Publisher Copyright:
© Medicina Oral S. L. C.I.F.

Keywords

  • Mouth neoplasm
  • carcinoma in-situ
  • diagnosis
  • microinvasive
  • oral squamous cell carcinoma
  • Carcinoma, Squamous Cell/epidemiology
  • South America/epidemiology
  • Cross-Sectional Studies
  • Humans
  • Mouth Neoplasms/epidemiology
  • Middle Aged
  • Male
  • Aged, 80 and over
  • Female
  • Adult
  • Aged

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