Innate immune system and preeclampsia

Alejandra Perez-Sepulveda, Maria Jose Torres, Maroun Khoury, Sebastian E. Illanes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE

Original languageEnglish
Article number244
JournalFrontiers in Immunology
Issue numberMAY
StatePublished - 2014

Bibliographical note

© 2014 Perez-Sepulveda, Torres, Khoury and Illanes.


  • Immunomodulation
  • Mesenchymal stem cells
  • Preeclampsia
  • Th1-th17
  • Th2-treg


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