Impact of head and neck radiotherapy on the longevity of dental adhesive restorations: A systematic review and meta-analysis

Natália Rangel Palmier, Cristhian Camilo Madrid Troconis, Ana Gabriela Costa Normando, Eliete Neves Silva Guerra, Anna Luíza Damaceno Araújo, Lady Paola Aristizábal Arboleda, Jéssica Montenegro Fonsêca, Mariana de Pauli Paglioni, Wagner Gomes-Silva, Aljomar José Vechiato Filho, Wilfredo Alejandro González-Arriagada, Adriana Franco Paes Leme, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Mario Fernando de Goes, Marcio Ajudarte Lopes, Alan Roger Santos-Silva

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Statement of problem: Established restorative protocols for patients after head and neck radiotherapy are lacking, increasing the failure rates of dental adhesive restorations. Purpose: The purpose of this systematic review and meta-analysis was to analyze the evidence regarding the impact of head and neck radiotherapy on the longevity of dental adhesive restorations. Material and methods: A search was performed using PubMed, Scopus, and Embase in May 2018 (updated in November 2020). Data extraction was performed regarding the percentage of restoration failure among dental adhesive materials, including glass ionomer cements, resin-modified glass ionomer cements, and composite resins. Risk of bias was assessed by the meta-analysis of statistics assessment and review instrument (MAStARI). Confidence in cumulative evidence was evaluated by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) protocol. Results: Four studies met the inclusion criteria. All included studies were classified as having a moderate risk of bias and reported results regarding class V restorations. Overall, composite resins presented lower failure rates at 2 years (30%) when compared with resin-modified glass ionomer (41%) and glass ionomer cements (57%). Meta-analysis showed that the risk of failure with glass ionomer cements was greater than with resin-modified glass ionomer cements (RR: 1.71, P<.001). Composite resins presented lower risk of failure when compared with glass ionomer (RR: 2.29, P<.001) and resin-modified glass ionomer cements (RR: 1.30, P=.03). Three studies reported results regarding fluoride compliance, which had a negative effect on the survival rates of glass ionomer and resin-modified glass ionomer cements and a positive effect on composite resin restorations. Conclusions: The results suggest that composite resin restorations associated with fluoride gel compliance seems to be the best alternative for restoring class V lesions in patients after head and neck radiotherapy. However, the results showed moderate certainty of evidence, which justifies the need for more randomized clinical trials regarding this subject.

Original languageEnglish
Pages (from-to)68-8
Number of pages8
JournalThe Journal of Prosthetic Dentistry
Early online date11 Mar 2021
StatePublished - 2021

Bibliographical note

Funding Information:
The authors thank S?o Paulo Research Foundation (FAPESP) for financial support (process numbers 2018/04657-8; 2018/02233-6; 2016/22862-2; 2013/18402-8 and 2012/06138-1) and the National Council for Scientific and Technological Development (CNPq), Brazil. The authors also state that this study was financed in part by the Coordination for the Improvement of Higher Education Personnel -Brazil (CAPES)- Finance Code 001.

Publisher Copyright:
© 2021 Editorial Council for the Journal of Prosthetic Dentistry


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