IL-33 enhances retinoic acid signaling on CD4+ T cells

Tania Gajardo, Francisco Pérez, Claudia Terraza, Mauricio Campos-Mora, Randolph J. Noelle, Karina Pino-Lagos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Several molecules have been described as CD4+ T cells differentiation modulators and among them retinoic acid (RA) and more recently, IL-33, have been studied. Due to the similarities in T helper cell skewing properties between RA and IL-33, we asked whether IL-33 intersects, directly or indirectly, the RA signaling pathway. Total CD4+ T cells from DR5-luciferase mice were activated in the presence of RA with or without IL-33, and RA signaling was visualized using ex vivo imaging. Our results demonstrate that IL-33 itself is able to trigger RA signaling on CD4+ T cells, which is highly increased when IL-33 is added in conjunction with RA. This study presents IL-33 as a potential player that may synergize with RA in controlling T cell differentiation, and suggests that IL-33 may be an attractive target in controlling T cell differentiation in vivo.

Original languageEnglish
Pages (from-to)120-122
Number of pages3
StatePublished - 1 Sep 2016

Bibliographical note

Funding Information:
This work was supported by FONDECYT Grant 11121309 and PMI UAN1301 .

Publisher Copyright:
© 2016 Elsevier Ltd.


  • CD4+ T cells differentiation
  • IL-33
  • Retinoic acid


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