TY - JOUR
T1 - How to enhance MSCs therapeutic properties? An insight on potentiation methods
AU - Guerrero, Cynthia Aylín García
AU - Fuentes, Paloma
AU - Araya, María Jesús
AU - Djouad, Farida
AU - Luz-Crawford, Patricia
AU - Vega-Letter, Ana María
AU - Altamirano, Claudia
N1 - Publisher Copyright:
© 2024. The Author(s).
PY - 2024/9/27
Y1 - 2024/9/27
N2 - Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and exert paracrine effects. However, despite encouraging results obtained in preclinical studies, clinical trials have not achieved the same levels of efficacy. To improve the therapeutic properties of MSCs, several strategies have been explored. Therefore, in this review, the therapeutic properties of MSCs will be analyzed, and an update and overview of the most prominent approaches used to enhance their therapeutic capabilities will be provided. These approaches include using drugs, molecules, strategies based on biomaterials, and modification parameters in culture. The strategy described shows several common factors among those affected by these strategies that lead to an enhancement of the MSCs therapeutic properties such as the activation of the PI3K/AKT pathway and the increased expression of Heat Shock Proteins and Hypoxia-Inducible Factor. The combined effect of these elements shift MSCs towards a glycolytic state, suggesting this shift is essential for their enhancement.
AB - Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and exert paracrine effects. However, despite encouraging results obtained in preclinical studies, clinical trials have not achieved the same levels of efficacy. To improve the therapeutic properties of MSCs, several strategies have been explored. Therefore, in this review, the therapeutic properties of MSCs will be analyzed, and an update and overview of the most prominent approaches used to enhance their therapeutic capabilities will be provided. These approaches include using drugs, molecules, strategies based on biomaterials, and modification parameters in culture. The strategy described shows several common factors among those affected by these strategies that lead to an enhancement of the MSCs therapeutic properties such as the activation of the PI3K/AKT pathway and the increased expression of Heat Shock Proteins and Hypoxia-Inducible Factor. The combined effect of these elements shift MSCs towards a glycolytic state, suggesting this shift is essential for their enhancement.
KW - Anti-inflammatory
KW - Immunomodulatory
KW - Mesenchymal stem cells
KW - Potentiation
KW - Regenerative medicine
KW - Therapeutic properties
UR - http://www.scopus.com/inward/record.url?scp=85205335582&partnerID=8YFLogxK
U2 - 10.1186/s13287-024-03935-6
DO - 10.1186/s13287-024-03935-6
M3 - Review article
C2 - 39334487
AN - SCOPUS:85205335582
SN - 1757-6512
VL - 15
SP - 331
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 1
ER -