Abstract
BACKGROUND: Microinvasive oral squamous cell carcinoma (OSCCmi) is an incipient stage of oral cancer. Through this systematic review, we aim to assess patterns of histopathological outcomes reported in OSCCmi cases. MATERIAL AND METHODS: An online search in major databases was performed without period restriction, and 2,024 publications in English, Spanish and Portuguese were obtained. After screening and eligibility, 4 studies were selected. The risk of bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. A descriptive synthesis was conducted. RESULTS: All 4 publications included were retrospective, reporting a total of 116 OSCCmi patients, with a male predominance (1.6:1) and a mean age of 55.9 years. The main parameters considered for microinvasion were tumor thickness (TT) (range 4-10mm) and depth of invasion (DOI) (range 0,02-5mm). Definition, cut-off values, and assessment of microscopic features were not standardized. Other relevant measures such as perineural or lymphovascular invasion and pattern of invasive front were barely described, and cytological/architectural characteristics were not discussed. CONCLUSIONS: TT and DOI are currently the primary histopathological criteria used to define OSCCmi. Nonetheless, the outcomes of this systematic review showed the absence of standardized quantitative parameters to render the diagnosis of microinvasive OSCC. Therefore, additional studies aiming to standardize histopathological features to diagnose OSCCmi are paramount.
Original language | English |
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Article number | 25675 |
Pages (from-to) | e255-e263 |
Number of pages | 9 |
Journal | Medicina Oral, Patologia Oral y Cirugia Bucal |
Volume | 28 |
Issue number | 3 |
Early online date | 24 Dec 2022 |
DOIs | |
State | Published - 1 May 2023 |
Bibliographical note
Publisher Copyright:© Medicina Oral S. L. C.I.F..
Keywords
- Microinvasive
- histopathological profile
- microinvasion
- oral cancer
- oral squamous cell carcinoma
- systematic review