TY - JOUR
T1 - Hexose Transporters in Cancer
T2 - From Multifunctionality to Diagnosis and Therapy
AU - Echeverría, Carolina
AU - Nualart, Francisco
AU - Ferrada, Luciano
AU - Smith, Gary J.
AU - Godoy, Alejandro S.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Cancer cells increase their metabolic activity by enhancing glucose uptake through overexpression of hexose transporters (Gluts). Gluts also have the capacity to transport other molecules besides glucose, including fructose, mannose, and dehydroascorbic acid (DHA), the oxidized form of vitamin C. The majority of research studies in this field have focused on the role of glucose transport and metabolism in cancer, leaving a substantial gap in our knowledge of the contribution of other hexoses and DHA in cancer biology. Here, we summarize the most recent advances in understanding the role that the multifunctional transport capacity of Gluts plays in biological and clinical aspects of cancer, and how these characteristics can be exploited in the search for novel diagnostic and therapeutic strategies.
AB - Cancer cells increase their metabolic activity by enhancing glucose uptake through overexpression of hexose transporters (Gluts). Gluts also have the capacity to transport other molecules besides glucose, including fructose, mannose, and dehydroascorbic acid (DHA), the oxidized form of vitamin C. The majority of research studies in this field have focused on the role of glucose transport and metabolism in cancer, leaving a substantial gap in our knowledge of the contribution of other hexoses and DHA in cancer biology. Here, we summarize the most recent advances in understanding the role that the multifunctional transport capacity of Gluts plays in biological and clinical aspects of cancer, and how these characteristics can be exploited in the search for novel diagnostic and therapeutic strategies.
KW - cancer metabolism
KW - dehydroascorbic acid
KW - fructose
KW - glucose
KW - glucose transporters
KW - mannose
UR - http://www.scopus.com/inward/record.url?scp=85100000746&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2020.12.006
DO - 10.1016/j.tem.2020.12.006
M3 - Article
C2 - 33518451
AN - SCOPUS:85100000746
SN - 1043-2760
VL - 32
SP - 198
EP - 211
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -