Global and local mechanisms sustain axonal proteostasis of transmembrane proteins

Víctor Hugo Cornejo, Alejandro Luarte, Andrés Couve*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The control of neuronal protein homeostasis or cursive is tightly regulated both spatially and temporally, assuring accurate and integrated responses to external or intrinsic stimuli. Local or autonomous responses in dendritic and axonal compartments are crucial to sustain function during development, physiology and in response to damage or disease. Axons are responsible for generating and propagating electrical impulses in neurons, and the establishment and maintenance of their molecular composition are subject to extreme constraints exerted by length and size. Proteins that require the secretory pathway, such as receptors, transporters, ion channels or cell adhesion molecules, are fundamental for axonal function, but whether axons regulate their abundance autonomously and how they achieve this is not clear. Evidence supports the role of three complementary mechanisms to maintain proteostasis of these axonal proteins, namely vesicular transport, local translation and trafficking and transfer from supporting cells. Here, we review these mechanisms, their molecular machineries and contribution to neuronal function. We also examine the signaling pathways involved in local translation and their role during development and nerve injury. We discuss the relative contributions of a transport-controlled proteome directed by the soma (global regulation) versus a local-controlled proteome based on local translation or cell transfer (local regulation).

Original languageEnglish
Pages (from-to)255-266
Number of pages12
Issue number5
StatePublished - 1 May 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • axon
  • neurons
  • protein synthesis
  • proteome
  • proteostasis
  • trafficking
  • transmembrane proteins
  • transport


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