Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos, Anna Segarra-Fas, Gino Nardocci, Andrew Cassidy, Odetta Antico, Lindsay Davidson, Lennart Brandenburg, Thomas J. Macartney, Rachel Toth, C. James Hastie, Jennifer Moran, Robert Gourlay, Joby Varghese, Renata F. Soares, Martin Montecino, Greg M. Findlay*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

Original languageEnglish
Pages (from-to)629-647.e7
JournalDevelopmental Cell
Volume55
Issue number5
DOIs
StatePublished - 7 Dec 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

  • development
  • metazoan evolution
  • neural development
  • neurodevelopmental disorders
  • protein kinase
  • protein phosphorylation
  • signal transduction
  • stem cells
  • transcriptomics
  • ubiquitin signaling

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