Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos; Anna Segarra-Fas; Gino Nardocci; Andrew Cassidy; Odetta Antico; Lindsay Davidson; Lennart Brandenburg; Thomas J. Macartney; Rachel Toth; C. James Hastie; Jennifer Moran; Robert Gourlay; Joby Varghese; Renata F. Soares; Martin Montecino; Greg M. Findlay

doi:10.1016/j.devcel.2020.09.025

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos, Anna Segarra-Fas, Gino Nardocci, Andrew Cassidy, Odetta Antico, Lindsay Davidson, Lennart Brandenburg, Thomas J. Macartney, Rachel Toth, C. James Hastie, Jennifer Moran, Robert Gourlay, Joby Varghese, Renata F. Soares, Martin Montecino, Greg M. Findlay^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

Original language	English
Pages (from-to)	629-647.e7
Journal	Developmental Cell
Volume	55
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2020.09.025
State	Published - 7 Dec 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

development
metazoan evolution
neural development
neurodevelopmental disorders
protein kinase
protein phosphorylation
signal transduction
stem cells
transcriptomics
ubiquitin signaling

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10.1016/j.devcel.2020.09.025

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Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., Brandenburg, L., Macartney, T. J., Toth, R., Hastie, C. J., Moran, J., Gourlay, R., Varghese, J., Soares, R. F., Montecino, M., & Findlay, G. M. (2020). Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Developmental Cell, 55(5), 629-647.e7. https://doi.org/10.1016/j.devcel.2020.09.025

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title = "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling",

abstract = "Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.",

keywords = "development, metazoan evolution, neural development, neurodevelopmental disorders, protein kinase, protein phosphorylation, signal transduction, stem cells, transcriptomics, ubiquitin signaling",

author = "Francisco Bustos and Anna Segarra-Fas and Gino Nardocci and Andrew Cassidy and Odetta Antico and Lindsay Davidson and Lennart Brandenburg and Macartney, {Thomas J.} and Rachel Toth and Hastie, {C. James} and Jennifer Moran and Robert Gourlay and Joby Varghese and Soares, {Renata F.} and Martin Montecino and Findlay, {Greg M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = dec,

day = "7",

doi = "10.1016/j.devcel.2020.09.025",

language = "English",

volume = "55",

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Bustos, F, Segarra-Fas, A, Nardocci, G, Cassidy, A, Antico, O, Davidson, L, Brandenburg, L, Macartney, TJ, Toth, R, Hastie, CJ, Moran, J, Gourlay, R, Varghese, J, Soares, RF, Montecino, M & Findlay, GM 2020, 'Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling', Developmental Cell, vol. 55, no. 5, pp. 629-647.e7. https://doi.org/10.1016/j.devcel.2020.09.025

TY - JOUR

T1 - Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

AU - Bustos, Francisco

AU - Segarra-Fas, Anna

AU - Nardocci, Gino

AU - Cassidy, Andrew

AU - Antico, Odetta

AU - Davidson, Lindsay

AU - Brandenburg, Lennart

AU - Macartney, Thomas J.

AU - Toth, Rachel

AU - Hastie, C. James

AU - Moran, Jennifer

AU - Gourlay, Robert

AU - Varghese, Joby

AU - Soares, Renata F.

AU - Montecino, Martin

AU - Findlay, Greg M.

PY - 2020/12/7

Y1 - 2020/12/7

N2 - Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

AB - Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

KW - development

KW - metazoan evolution

KW - neural development

KW - neurodevelopmental disorders

KW - protein kinase

KW - protein phosphorylation

KW - signal transduction

KW - stem cells

KW - transcriptomics

KW - ubiquitin signaling

UR - http://www.scopus.com/inward/record.url?scp=85095412691&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2020.09.025

DO - 10.1016/j.devcel.2020.09.025

M3 - Article

C2 - 33080171

AN - SCOPUS:85095412691

SN - 1534-5807

VL - 55

SP - 629-647.e7

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Abstract

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Keywords

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