Fecal microbiota transplantation through colonoscopy for clostridium difficile recurrent infection. Report of eight cases

Rodrigo Quera, Patricio Ibáñez, Daniela Simian, Daniela Rivera, Guillermo Acuña, Ricardo Espinoza

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Most cases of Clostridium difficile infection (CDI) respond to a standard course of antibiotics, however recurrent CDI is becoming common and alternative therapeutic strategies are needed. In this scenario, fecal microbiota transplantation (FMT) has been suggested. Aim: To describe the efficacy and safety of FMT for the treatment of recurrent CDI. Patients and Methods: Review of medical records of all patients with recurrent CDI treated with FMT between April 2013 and April 2017. Demographic and clinical data were abstracted including details of treatment prior to FMT, rate of FMT treatment success and clinical course during follow-up period. Telephone surveys were conducted to determine patient satisfaction. Results: Eight patients aged 19 to 82 years (six women) underwent FMT. They experienced a median of four previous episodes of CDI (range 3-8). The mean duration of CDI was 18 days (range 3-36) before FMT. All procedures were performed by colonoscopy. Effectiveness with one session of FMT was 100%. During the follow-up period (median 24 months, range 7-55), two patients developed CDI, one of them after using antibiotics. Adverse events were reported in three patients. Two had bloating and one patient with Crohn’s disease and a history of bacteremia had an episode of Escherichia coli bacteremia. All patients would use FMT again if necessary. Conclusions: FMT through colonoscopy appears to be a safe, effective and long-lasting therapy in cases of recurrent CDI.

Translated title of the contributionFecal microbiota transplantation through colonoscopy for clostridium difficile recurrent infection. Report of eight cases
Original languageSpanish
Pages (from-to)823-830
Number of pages8
JournalRevista Medica de Chile
Volume146
Issue number8
DOIs
StatePublished - 2018
Externally publishedYes

Bibliographical note

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© 2018, Sociedad Medica de Santiago. All rights reserved.

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