Extracellular Vesicles from Immune Cells: a Biomedical Perspective

María José Moya-Guzmán, Javiera de Solminihac, Cristina Padilla, Carolina Rojas, Camila Pinto, Tomás Himmel, Karina Pino-Lagos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Research on the role of extracellular vesicles (sEV) in physiology has demonstrated their undoubted importance in processes such as the transportation of molecules with significance for cell metabolism, cell communication, and the regulation of mechanisms such as cell differentiation, inflammation, and immunity. Although the role of EVs in the immune response is actively investigated, there is little literature revising, in a comprehensive manner, the role of small EVs produced by immune cells. Here, we present a review of studies reporting the release of sEV by different types of leukocytes and the implications of such observations on cellular homeostasis. We also discuss the function of immune cell-derived sEV and their relationship with pathological states, highlighting their potential application in the biomedical field.

Original languageEnglish
Article number13775
Pages (from-to)1-19
Number of pages19
JournalInternational Journal of Molecular Sciences
Issue number18
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.


  • exosomes
  • extracellular vesicles
  • immune cells
  • immune regulation
  • immunity


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