Exploiting synergy: Immune-based combinations in the treatment of prostate cancer

Mauricio Burotto, Nishith Singh, Christopher R. Heery, James L. Gulley, Ravi A. Madan

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Cancer treatment is being revolutionized by the emergence of immunotherapies such as immune check point inhibitors and therapeutic cancer vaccines. Prostate cancer has is amenable to such therapeutic approaches. The improved understanding of the relationship between the immune system and tumors has allowed therapeutic targeting of immune checkpoints and tumor associated antigens to be developed. Furthermore, interventions used in prostate cancer are capable of impacting the immune system. As demonstrated by preclinical data and emerging clinical data, radiation therapy, anti-androgen therapy and chemotherapy can be used with immunotherapies to obtain synergistic results. Current and future clinical trials will further investigate these principals as immunotherapeutics are combined with each other and standard therapies for optimal clinical utility.

Original languageEnglish
Article number351
JournalFrontiers in Oncology
Volume4
Issue numberNOV
DOIs
StatePublished - 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Burotto, Singh_, Heery, Gulley and Madan.

Keywords

  • Check point inhibitors
  • Chemotherapy
  • Hormonal treatment
  • Immunotherapy
  • Prostate cancer
  • Radiation
  • Vaccines

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