A full-scale reinforced concrete building specimen, furnished with a variety of nonstructural components and systems (NCSs), was built and tested on the NEES (Network for Earthquake Engineering Simulation)-UCSD (University of California, San Diego) outdoor shake table in 2011-2012. The building specimen was subjected to a sequence of dynamic tests including scaled and unscaled historical earthquake ground motions. In order to simulate and predict the nonlinear dynamic response of the building specimen, a detailed three-dimensional nonlinear finite element (FE) model of the structure was developed utilizing the FE analysis software DIANA and used for pre-test response simulation as well as for guidance regarding the scaling of the input ground motions used for the shake table tests. Utilized as blind prediction, the pre-test simulated results were compared with the experimental results and important sources of discrepancies were identified. Some important sources of discrepancies are the kinematic interaction existing between the structure and some NCSs and the pinching behavior exhibited by RC structural components.