Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina

Translated title of the contribution: Cardiovascular assessment of non diabetic patients on hemodialysis

Sonia Kunstmann*, Antonio Vukusich, Luis Michea, Cristian Varela, Irene Allende, Sebastián Bravo, Daniela Gainza, Daniela Sepúlveda, Elisa Marusic, Fernando Figueroa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Diabetes mellitus is an important risk factor for cardiovascular complications among patients on hemodialysis. However, the incidence of these complications among non diabetic patients on hemodialysis is not well known. Aim: To assess the incidence of cardiovascular complications in non diabetic patients on hemodialysis. Patients and methods: Seventy five non diabetic patients aged 55.6 ± 17 years (48 males), receiving hemodialysis three times a week were evaluated with laboratory tests, echocardiogram and a carotid ultrasound. In 26 patients, interleukin 6, tumor necrosis factor alpha, and intercellular adhesion molecule (ICAM-1) were also measured. Patients were followed during two years. Results: The mean lapse of dialysis therapy was 6.5 ± 5 years. The main cause of renal failure was hypertension. Sixty two percent had systolic hypertension, 86% had concentric left ventricular hypertrophy, 43% had atrial dilatation and 60% had calcifications in the thoracic aorta. Compared with normal controls, patients had higher levels of interleukin 6, tumor necrosis factor alpha and ICAM-1. Carotid media thickness was also higher and increased in the two years of follow up. No correlations were found between ventricular hypertrophy and dialysis lapse, packed red cell volume, calcium phosphorus product, parathormone levels or median arterial pressure. No cardiovascular events were recorded during the follow up period. Conclusions: Non diabetic patients on chronic hemodialysis have a high frequency of ventricular hypertrophy, carotid media thickening, aortic calcifications and an increase in proinflammatory cytokines.

Translated title of the contributionCardiovascular assessment of non diabetic patients on hemodialysis
Original languageSpanish
Pages (from-to)351-360
Number of pages10
JournalRevista Medica de Chile
Issue number3
StatePublished - Mar 2009
Externally publishedYes


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