Eventos adversos en la terapia farmacológica de la enfermedad inflamatoria intestinal

Lital Meyer, Daniela Simian, Jaime Lubascher, Raúl Acuña, Carolina Figueroa, Guillermo Silva, Javier Brahm, Rodrigo Quera

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: The purpose of inflammatory bowel disease (IBD) treatment is to achieve resolution of symptoms and remission of disease with a minimum of adverse events (AE). Aim: To report AE of different prescriptions used for the treatment of IBD. Material and Methods: Analysis of a registry of patients with IBD held at a private clinic from 1976 to 2013. All used medications, the occurrence and severity of AE were recorded. Results: The records of 346 patients aged 16 to 86 years, 74% with ulcerative colitis, were analyzed. The most commonly type of medications prescribed were 5-aminosalicylates (5-ASAs) in 329 patients (92%), followed by adrenal steroids in 218 (61%). Forty nine AE were recorded in the same number of patents (14%). These were more common in patients with Crohn disease (n = 19, 21%). An univariate analysis, demonstrated that extra-intestinal manifestations, hospitalizations secondary to IBD crisis, requirement of surgery and treatment with steroids, immunosuppressants or biologic agents were significantly associated with the presence of AE. AEs were more common with immunosuppressants, followed by 5-ASAs and steroids. Discontinuation of therapy was required in 79, 100 and 43% of patients taking these medications, respectively. Twenty percent of AEs were severe. Leukopenia and pancytopenia along with alopecia were the most common AEs attributable to azathioprine. Conclusions: The occurrence of AEs in patients with IBD is uncommon. Even inmunosuppressants or biologic agents have a low rate of AE and most of them mild.

Translated title of the contributionEventos adversos en la terapia farmacológica de la enfermedad inflamatoria intestinal
Original languageSpanish
Pages (from-to)7-13
Number of pages7
JournalRevista Medica de Chile
Volume143
Issue number1
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015, Sociedad Medica de Santiago. All rights reserved.

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