Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

Catherine Bueno Domingueti; Dayana Aparecida Queiroz Castilho; Carine Ervolino de Oliveira; João Baptista Macuco Janini; Wilfredo Alejandro González-Arriagada; Tuula Salo; Ricardo D Coletta; Lívia Máris Ribeiro Paranaíba

doi:10.1016/j.oooo.2020.09.003

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

Catherine Bueno Domingueti
, Dayana Aparecida Queiroz Castilho
, Carine Ervolino de Oliveira
, João Baptista Macuco Janini
, Wilfredo Alejandro González-Arriagada
, Tuula Salo
, Ricardo D Coletta
, Lívia Máris Ribeiro Paranaíba

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

OBJECTIVE: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.

STUDY DESIGN: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.

RESULTS: High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.

CONCLUSIONS: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.

Original language	English
Pages (from-to)	700-707.e2
Number of pages	8
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	130
Issue number	6
DOIs	https://doi.org/10.1016/j.oooo.2020.09.003
State	Published - Dec 2020
Externally published	Yes

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarkers, Tumor
Cancer-Associated Fibroblasts
Carcinoma, Squamous Cell
Collagen Type I
Humans
Kaplan-Meier Estimate
Mouth Neoplasms
Peptide Elongation Factor 1
Prognosis

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10.1016/j.oooo.2020.09.003

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Domingueti, C. B., Castilho, D. A. Q., de Oliveira, C. E., Janini, J. B. M., González-Arriagada, W. A., Salo, T., Coletta, R. D., & Paranaíba, L. M. R. (2020). Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 130(6), 700-707.e2. https://doi.org/10.1016/j.oooo.2020.09.003

Domingueti, Catherine Bueno ; Castilho, Dayana Aparecida Queiroz ; de Oliveira, Carine Ervolino et al. / Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2020 ; Vol. 130, No. 6. pp. 700-707.e2.

@article{1b9fd14e12db4ca88bf1a0ae980ef543,

title = "Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients",

abstract = "OBJECTIVE: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.STUDY DESIGN: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.RESULTS: High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.CONCLUSIONS: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.",

keywords = "Biomarkers, Tumor, Cancer-Associated Fibroblasts, Carcinoma, Squamous Cell, Collagen Type I, Humans, Kaplan-Meier Estimate, Mouth Neoplasms, Peptide Elongation Factor 1, Prognosis",

author = "Domingueti, \{Catherine Bueno\} and Castilho, \{Dayana Aparecida Queiroz\} and \{de Oliveira\}, \{Carine Ervolino\} and Janini, \{Jo{\~a}o Baptista Macuco\} and Gonz{\'a}lez-Arriagada, \{Wilfredo Alejandro\} and Tuula Salo and Coletta, \{Ricardo D\} and Parana{\'i}ba, \{L{\'i}via M{\'a}ris Ribeiro\}",

note = "Copyright {\textcopyright} 2020. Published by Elsevier Inc.",

year = "2020",

month = dec,

doi = "10.1016/j.oooo.2020.09.003",

language = "English",

volume = "130",

pages = "700--707.e2",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "2212-4403",

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number = "6",

}

Domingueti, CB, Castilho, DAQ, de Oliveira, CE, Janini, JBM, González-Arriagada, WA, Salo, T, Coletta, RD & Paranaíba, LMR 2020, 'Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 130, no. 6, pp. 700-707.e2. https://doi.org/10.1016/j.oooo.2020.09.003

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients. / Domingueti, Catherine Bueno; Castilho, Dayana Aparecida Queiroz; de Oliveira, Carine Ervolino et al.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 130, No. 6, 12.2020, p. 700-707.e2.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

AU - Domingueti, Catherine Bueno

AU - Castilho, Dayana Aparecida Queiroz

AU - de Oliveira, Carine Ervolino

AU - Janini, João Baptista Macuco

AU - González-Arriagada, Wilfredo Alejandro

AU - Salo, Tuula

AU - Coletta, Ricardo D

AU - Paranaíba, Lívia Máris Ribeiro

PY - 2020/12

Y1 - 2020/12

N2 - OBJECTIVE: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.STUDY DESIGN: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.RESULTS: High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.CONCLUSIONS: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.

AB - OBJECTIVE: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.STUDY DESIGN: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.RESULTS: High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.CONCLUSIONS: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.

KW - Biomarkers, Tumor

KW - Cancer-Associated Fibroblasts

KW - Carcinoma, Squamous Cell

KW - Collagen Type I

KW - Humans

KW - Kaplan-Meier Estimate

KW - Mouth Neoplasms

KW - Peptide Elongation Factor 1

KW - Prognosis

U2 - 10.1016/j.oooo.2020.09.003

DO - 10.1016/j.oooo.2020.09.003

M3 - Article

C2 - 33132084

SN - 2212-4403

VL - 130

SP - 700-707.e2

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 6

ER -

Domingueti CB, Castilho DAQ, de Oliveira CE, Janini JBM, González-Arriagada WA, Salo T et al. Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2020 Dec;130(6):700-707.e2. doi: 10.1016/j.oooo.2020.09.003

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this