Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury

Luis Toro, Víctor Barrientos, Pablo León, Macarena Rojas, Magdalena Gonzalez, Alvaro González-Ibáñez, Sebastián Illanes, Keigo Sugikawa, Néstor Abarzúa, César Bascuñán, Katherine Arcos, Carlos Fuentealba, Ana María Tong, Alvaro A. Elorza, María Eugenia Pinto, Rodrigo Alzamora, Carlos Romero, Luis Michea

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in bone marrow and potential contribution to circulating FGF23 has not been well studied. Moreover, recent studies show that plasma FGF23 may increase early during acute kidney injury (AKI). Erythropoietin, a kidney-derived hormone that targets erythropoietic cells, increases in AKI. Here we tested whether an acute increase of plasma erythropoietin induces FGF23 expression in erythropoietic cells of bone marrow thereby contributing to the increase of circulating FGF23 in AKI. We found that erythroid progenitor cells of bone marrow express FGF23. Erythropoietin increased FGF23 expression in vivo and in bone marrow cell cultures via the homodimeric erythropoietin receptor. In experimental AKI secondary to hemorrhagic shock or sepsis in rodents, there was a rapid increase of plasma erythropoietin, and an induction of bone marrow FGF23 expression together with a rapid increase of circulating FGF23. Blockade of the erythropoietin receptor fully prevented the induction of bone marrow FGF23 and partially suppressed the increase of circulating FGF23. Finally, there was an early increase of both circulating FGF23 and erythropoietin in a cohort of patients with severe sepsis who developed AKI within 48 hours of admission. Thus, increases in plasma erythropoietin and erythropoietin receptor activation are mechanisms implicated in the increase of plasma FGF23 in AKI.
Original languageAmerican English
Pages (from-to)1131-1141
Number of pages11
JournalKidney International
Volume93
Issue number5
DOIs
StatePublished - 1 May 2018

Keywords

  • acute kidney injury
  • bone
  • erythropoietin
  • FGF23
  • sepsis

Fingerprint Dive into the research topics of 'Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury'. Together they form a unique fingerprint.

Cite this