Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Ursula Wyneken; Juan Jose Marengo; Sergio Villanueva; Dagoberto Soto; Rodrigo Sandoval; Eckart D. Gundelfinger; Fernando Orrego

doi:10.1046/j.1528-1157.2003.17602.x

Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Ursula Wyneken^*, Juan Jose Marengo, Sergio Villanueva, Dagoberto Soto, Rodrigo Sandoval, Eckart D. Gundelfinger, Fernando Orrego

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

Original language	English
Pages (from-to)	243-246
Number of pages	4
Journal	Epilepsia
Volume	44
Issue number	2
DOIs	https://doi.org/10.1046/j.1528-1157.2003.17602.x
State	Published - 1 Feb 2003

Keywords

NMDA receptor Trk B
Postsynaptic densities

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10.1046/j.1528-1157.2003.17602.x

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title = "Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities",

abstract = "Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.",

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TY - JOUR

T1 - Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

AU - Wyneken, Ursula

AU - Marengo, Juan Jose

AU - Villanueva, Sergio

AU - Soto, Dagoberto

AU - Sandoval, Rodrigo

AU - Gundelfinger, Eckart D.

AU - Orrego, Fernando

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

AB - Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

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KW - Postsynaptic densities

KW - NMDA receptor Trk B

KW - Postsynaptic densities

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Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

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Keywords

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