Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Ursula Wyneken, Juan Jose Marengo, Sergio Villanueva, Dagoberto Soto, Rodrigo Sandoval, Eckart D. Gundelfinger, Fernando Orrego

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.
Original languageAmerican English
Pages (from-to)243-246
Number of pages4
JournalEpilepsia
Volume44
Issue number2
DOIs
StatePublished - 1 Feb 2003

Keywords

  • NMDA receptor Trk B
  • Postsynaptic densities

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