Efficacy on supragingival plaque control of cetylpyridinium chloride in a slow‐release dosage form

Betty N.A. Vandekerckhove, Daniel Van Steenberghe, Jorge Tricio, David Rosenberg, Myriam Encarnacion

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Abstract To evaluate the relative efficacy of a non‐degradable osmotic slow‐release dosage form containing 6.6 mg cetylpyridinium chloride (MOTS [Mucosal Oral Therapeutic System] CPC) to inhibit new plaque formation and gingivitis, a single‐blind, randomised, parallel group pilot study was set up. 52 healthy volunteers were assigned to receive one of the following treatments for 18 days of non‐brushing: holding 1 MOTS CPC 2× daily for 2 h intra‐orally, or rinsing 30 s with 15 ml Peridex® 2× daily, or dissolve Cepacol® (each 1.6 mg CPC) lozenges 2× daily unsupervised. Before the test period, the subejcts received a thorough tooth cleaning followed by tooth polishing 1× a week for 3 weeks to achieve clinical gingival health. After the start of therapy, the subjects were examined at day 4, 7 (±2), 14 (±2) and 18 (2±). Relative efficacy was assessed by the modified Navy plaque index, the Quigley and Hein index, the planimetric plaque index, as well as the papillary marginal gingival index. There was an increase in both plaque formation and gingivitis over the 18±2 day period of non‐brushing for all subjects in the study. Peridex® was the most effective in inhibiting plaque and gingivitis formation over that period of time. There was no difference between MOTS CPC and Cepacol® at any time point in plaque accumulation and gingivitis intensity. Peridex® was considered more convenient than MOTS CPC. Cepacol® resulted in more staining at 18 days than MOTS CPC and Peridex®.

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalJournal of Clinical Periodontology
Issue number11
StatePublished - Nov 1995
Externally publishedYes


  • cetylpyridinium chloride
  • chlorhexidine rinse
  • controlled release system
  • gingival index
  • plaque index

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