Efficacy of the entire papilla preservation technique with or without L-PRF for the treatment of infrabony defects: pilot clinical study

Objectives: Infraosseous periodontal defects are a challenge for restoring periodontal health. Regenerative techniques such as entire papilla preservation (EPP) offer valid, minimally invasive alternatives. Platelet concentrates like leukocyte-and platelet-rich fibrin (L-PRF) may enhance the healing process. This pilot study aims to describe and assess the effectiveness of EPP for treating interproximal infrabony defects, with and without L-PRF, focusing on clinical and radiographic parameters. Method and materials: The study included 11 cases from seven patients treated at University of Los Andes Health Center. Periodontal defects with probing depth ≥ 6 mm were treated using EPP. L-PRF was added in five defects, placed intraosseously. Clinical and radiographic parameters were evaluated at baseline and 6 months postsurgery. Results: Probing depth decreased by a mean of 4.27 mm (P < .05), with a clinical attachment level gain of 3.70 mm (P < .05). No significant differences were observed between groups. Gingival margin position tended to recess in the EPP group (variation: −1.0 ± 0.7 mm) but remained stable in the EPP + L-PRF group (variation: 0.3 ± 0.5 mm). Postoperative pain on the visual analog scale was significantly lower at 24 and 72 hours with L-PRF (P < .03). No complications were reported. Conclusions: EPP has a positive effect on clinical and radiographic parameters, whether used alone or with L-PRF. L-PRF appears to improve postoperative pain and gingival margin stability in the medium term. This technique offers a low cost, minimally invasive option for periodontal regeneration with minimal complications.