Efficacy and safety of misoprostol, dinoprostone and Cook’s balloon for labour induction in women with foetal growth restriction at term

Jorge Duro-Gómez, María Fernanda Garrido-Oyarzún, Ana Belén Rodríguez-Marín, Antonio Jesús de la Torre González, José Eduardo Arjona-Berral, Camil Castelo-Branco

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background and objectives: To compare effectiveness and safety of dinoprostone, misoprostol and Cook’s balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. Methods: Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery. Obstetric and perinatal outcomes were also collected. Results: A total of 99 women were diagnosed with IUGR in the mentioned period. Of them, 21 women were induced with dinoprostone [dinoprostone group (DG)], 20 with misoprostol (MG) and in 58 with Cook’s balloon (CG). Groups were homogeneous regarding pre-induction Bishop score and parity. The CG required more time (24.36 vs. 19.23 h; p = 0.02) and more oxytocin dose for conduction of labour from induction to delivery (6.75 vs. 1.24 mUI; p < 0.01) than DG. Moreover, the CG also needed more oxytocin than MG, 6.75 vs. 2.37 mUI (p < 0.001). Caesarean rate was 5, 14.9 and 17.3% in MG, DG and CG, respectively. No differences were observed in rates of uterine tachysystole, non-reassuring foetal status and neonatal adverse events. Interpretation and conclusions: Prostaglandins were more effective than Cook’s balloon to induce labour and achieve vaginal birth in this sample of women with IUGR at term, with a similar safety profile.
Original languageAmerican English
Pages (from-to)777-781
Number of pages5
JournalArchives of Gynecology and Obstetrics
Volume296
Issue number4
DOIs
StatePublished - 1 Oct 2017

Keywords

  • Dinoprostone
  • Induction labour
  • Intrauterine growth restriction
  • Mechanical methods
  • Misoprostol

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