Diagnostic and management approach to pouchitis in inflammatory bowel disease

Rocío Sedano, Paulina Nuñez, Rodrigo Quera

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

– In patients with ulcerative colitis refractory to medical therapy, total proctocolectomy and posterior ileal-anal pouch anastomosis is the standard surgical therapy. One of the possible complications is pouchitis. Depending on the duration of the symptoms, it can be classified as acute, recurrent, or chronic. The latter, according to the response to therapy, can be defined as antibiotic-dependent or refractory. The treatment of pouchitis is based on the use of antibiotics and probiotics. Thiopurine and biological therapy have been suggested in patients with refractory pouchitis. Special care should be taken in the endoscopic surveillance of these patients, especially if they present risk factors such as dysplasia or previous colorectal cancer, primary sclerosing cholangitis or ulcerative colitis for more than 10 years.

Translated title of the contributionDiagnostic and management approach to pouchitis in inflammatory bowel disease
Original languagePortuguese
Pages (from-to)100-106
Number of pages7
JournalArquivos de Gastroenterologia
Volume57
Issue number1
DOIs
StatePublished - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020, IBEPEGE - Inst. Bras. Estudos Pesquisas Gastroent.. All rights reserved.

Keywords

  • Pouchitis
  • Restorative proctocolectomy
  • Therapy
  • Ulcerative colitis

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